Abstract: FR-PO1041
Kidney Donor Profile Index (KDPI) Predicts Outcome of Deceased Donor Kidney Transplant in a Brazilian Center
Session Information
- Transplantation: Donor-Candidate Assessment and Predictors of Outcome
November 03, 2017 | Location: Hall H, Morial Convention Center
Abstract Time: 10:00 AM - 10:00 AM
Category: Transplantation
- 1702 Transplantation: Clinical and Translational
Authors
- Felipe, Carlos rafael Almeida, Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
- Alvarenga, Andre Sousa, Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
- Miranda, Silvana Maria Carvalho, Hospital Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
- Jorge, Ana elisa Souza, Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
- Souza, Pedro Augusto Macedo, None, Belo Horizonte, MINAS GERAIS, Brazil
- Piana, Izabela Lara, Faculdade de Minas Faminas BH, Belo Horizonte, Brazil
Background
Kidney Donor Profile Index (KDPI) is a well-established index to predict the outcome of deceased donor renal transplant (DDRT), but it has not been established for brazillian population.
Methods
We retrospectively calculated the KDPI and analyzed the outcomes of 45 consecutives DDRT from November/2014 to March/2016: mean cold ischemia time (CIT) was 13.9 hours; the incidence of delayed graft function (DGF). The median of KDPI was 53%.
Results
Patients who died had higher KDPI (median 82.0% vs 50.5%; p 0.018), as well as those with allograft failure (median 77.0% vs 50.5%; p 0.021). The area under the KDPI ROC curve for the composite outcome of death or graft loss was 0.80 (Figure1), similar to donor serum creatinine. One year graft survival was 40% for kidneys with KDPI > 70% versus 84.5% for kidneys with KDPI < 70% (relative risk = 4.81; p 0.003). There was no association between KPDI > 70% and cytomegalovirus (CMV) infection. Donor age, final donor creatinine and expanded criteria donor were also associated with death and allograft failure (Table 1).
Conclusion
KDPI accurately predicted graft survival after DDRT and may be helpful in selecting and allocating a deceased kidney in Brazilian population.
Table 1: Study population data and outcomes
| Functioning Graft (n=34) | Graft Loss/Death (n=11) | p | |
| KDPI (%) – mean | 48.7 | 72.3 | 0.002 |
| Donor age (years) – mean | 41.2 | 49.9 | 0.037 |
| Final donor creatinine (mg/dL) – median | 0.92 | 2.60 | 0.002 |
| Expanded criteria donor (%) | 12.5 | 54.5 | 0.003 |
| Cold ischemia time (h) - mean | 12.7 | 16.2 | 0.055 |
| Receptor age (years) - median | 54.2 | 51.4 | 0.931 |
| DGF (%) | 55.9 | 81.8 | 0.164 |
| Stroke (%) | 61.8 | 90.1 | 0.131 |
| Female donor (%) | 41.2 | 36.4 | >0.999 |
| Biopsy proven acute kidney rejection (%) | 27.3 | 9.0 | 0.4082 |
| CMV disease (%) | 45.5 | 18.2 | 0.1585 |