Abstract: SA-PO1084

Relationship between Blood Pressure and Estimated Glomerular Filtrating Ratio or Proteinuria without a Life-Related Disease

Session Information

Category: Hypertension

  • 1102 Hypertension: Basic and Experimental - Renal Causes and Consequences

Authors

  • Kawashima, Masatoshi, Central Japan Railway Company, Tokyo, Japan
  • Kuma, Akihiro, Central Japan Railway Inc., Shizuoka, Japan
  • Enta, Kazuhiko, Central Japan Railway Company, Nagoya, Japan
Background

Both estimated glomerular filtrating ratio (eGFR) and proteinuria influences to systolic and diastolic blood presure. We examined the relationship between blood pressure and estimated glomerular filtrating ratio or proteinuria in the absence of a life-related disease.

Methods

We collected the yearly medical examination data from 2008 to 2015 of workers in a railway company in Japan. The data of individuals without a life-related disease, such as hypertension, diabetes mellitus, dyslipidemia, and hyperuricemia, were selected.
The selected individuals were classified into 3 categories by average eGFR from 2008 to 2015. Categories I, II, and III were ≥90, 60–90, and <60 ml/min/1.73m2, respectively. The individuals were next classified into 3 categories by the number of proteinuria reports from 2008 to 2015. Categories 0, 1, and 2 were 0, 1, and ≥2 reports, respectively.
Category I–III and Category 0–2 were then combined to form 9 categories (Category I0-III2) and their relationship to systolic and diastolic blood pressure in 2014 examined using ANCOVA with adjusted age and gender.

Results

The selected group of workers included 7,042 (female 336) workers of 24–64 years old in 2015. For systolic blood pressure, significant differences showed in 2 combinations (II0 and II2 P=0.029, and II1 and II2 P<0.001) in association with the proteinuria category. For diastolic blood pressure, a significant difference showed in 2 combinations (II0 and II2 P=0.027, and II1 and II2 P=0.003) in association with the proteinuria category. There were no significant differences detected in comparisons of the eGFR categories with systolic and diastolic blood pressures.

Conclusion

A relationship was detected between proteinuria and blood pressure, which appeared to be a stronger relationship than the relationship between eGFR and blood pressure.