Abstract: TH-PO936

Extracellular Fluid Excess Is Significantly Associated with Coronary Artery Calcification in Kidney Transplant Recipients

Session Information

Category: Transplantation

  • 1702 Transplantation: Clinical and Translational

Authors

  • Park, Seohyun, College of Medicine, Institute of Kidney Disease Research, Yonsei University,, Seoul, Korea (the Republic of)
  • Choi, Arum, College of Medicine, Severance Biomedical Science Institute, Brain Korea 23 PLUS, Yonsei University, Seoul, Korea (the Republic of)
  • Koh, Heebyung, College of Medicine, Institute of Kidney Disease Research, Yonsei University,, Seoul, Korea (the Republic of)
  • Kwon, Jaeyeol, College of Medicine, Institute of Kidney Disease Research, Yonsei University,, Seoul, Korea (the Republic of)
  • Yoo, Tae-Hyun, College of Medicine, Institute of Kidney Disease Research, Yonsei University,, Seoul, Korea (the Republic of)
Background

Coronary artery calcification (CAC) is associated with increased mortality in CKD patients and does not regress after kidney transplantation. Extracellular fluid excess measured by bio-impedance analysis (BIA) is also associated with adverse clinical outcomes in kidney transplant recipients (KTR). Present study is aimed to identify the relationship between extracellular volume status and CAC in KTR.

Methods

We evaluated 123 KTR of CMERC-HI (Cardiovascular and Metabolic Disease Etiology Research Center-High Risk, NCT02003781), a prospective observational cohort study of high risk patients with cardiovascular disease. Extracellular volume status was assessed by BIA and extracellular fluid excess (EFE) was defined if the ratio of extracellular water and total body water (ECW/TBW) was more than 0.390. CAC was measured by multi-detector CT and CAC ≥400 was considered as a calcified coronary artery.

Results

In this study, fifty-four (43.9%) patients showed excess with body fluid. Compared with non-EFE group, EFE group was older and had a longer time on KT, a longer duration of previous dialysis, and a lower estimated glomerular filtration rate (eGFR). The CACS and the proportion of calcified coronary artery were significantly higher in the EFE group. In logistic regression analysis, EFE was significantly associated with calcified coronary artery. Moreover, EFE was found to be independently associated with calcified coronary artery after adjustment for multiple confounders (Odds ratio; 4.327, 95% confidence interval; 1.309 – 14.298, P = 0.016).

Conclusion

Our study demonstrated that extracellular volume excess was significantly associated with CAC in KTR. Present study suggests that EFE might be a risk factor for cardiovascular disease in KTR.