Abstract: FR-PO823

Baseline Muscle Strength, Dry Weight, and Physical Activity Are Associated with Muscle Strengthening of Lower Extremities after 6-Month Resistance Training in Patients with Maintenance Hemodialysis

Session Information

Category: Dialysis

  • 601 Standard Hemodialysis for ESRD

Authors

  • Moriiyama, Yoshifumi, Nagoya kyoritsu hospital, Nagoya, Japan
  • Aratani, Sae, Nippon Medical School Hospital, Tokyo, Japan
  • Hara, Masahiko, Osaka City University Graduate School of Medicine, Osaka, Japan
  • Ishikawa, Hideaki, Konan Kosei Hospital, Konan, Japan
Background

Rapid muscle wasting is a common complication in patients with maintenance hemodialysis, and it is associated with the risk of pratfall as well as with poor quality of life and survival.

Methods

We included 271 patients who underwent 6-month resistance training program during hemodialysis. Primary outcome measure was change in percent knee extension muscle power to body weight (pKEMP-BW; mean of right and left) during 6-month. We divided our patients into 2 groups; improve vs deteriorate groups. Multivariable logistic regression model was employed to evaluate parameters which are associated with improvement of pKEMP-BW at 6-month, using indices shown in the Table as explanatory variables such as baseline pKEMP-BW or short physical performance battery (SPPB).

Results

Median age was 71 (quartile 64-77) years old, 144 patients (53.1%) were men, and median dry weight was 54.2 (47.5-61.6) kg. After 6-month training, pKEMP-BW was improved in 177 patients (65.3%), and pKEMP-BW changed from 42.0 (32.4-52.3) % to 43.4 (34.8-55.0) % in total (p<0.001). As shown in the Table, baseline lower dry weight, higher handgrip, lower pKEMP-BW, and higher SPPB were associated with an improvement of pKEMP-BW at 6-month.

Conclusion

Six-month resistance training improved pKEMP-BW. Baseline lower dry weight, higher handgrip, lower pKEMP-BW, and higher SPPB were associated with an improvement of pKEMP-BW at 6-month in patients with maintenance hemodialysis.