Kidney Week

Abstract: FR-PO442

The Association between Alcohol Consumption and Renal Outcome Is Modified by CKD Stages: The Results from the KNOW-CKD

Session Information

• CKD: Risk Factors for Incidence and Progression - II
  November 03, 2017 | Location: Hall H, Morial Convention Center
  Abstract Time: 10:00 AM - 10:00 AM

Category: Chronic Kidney Disease (Non-Dialysis)

• 301 CKD: Risk Factors for Incidence and Progression

Authors

• Koh, Heebyung, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea (the Republic of)

Heebyung Koh,

• Kwon, Jaeyeol, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea (the Republic of)

Jaeyeol Kwon,

• Nam, Ki Heon, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea (the Republic of)

Ki Heon Nam,

• An, Seong yeong, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea (the Republic of)

Seong yeong An,

• Han, Seung Hyeok, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea (the Republic of)

Seung Hyeok Han,

Background

Several studies have suggested that moderate alcohol drinking exhibits beneficial effects on the development of CKD. However, studies that examined the association between alcohol consumption and progression of CKD in patients with CKD are scarce.

Methods

We analyzed drinking pattern according to CKD stages and examined the association between alcohol consumption and CKD progression using the database from the prospective KoreaN cohort study for Outcome in patients With CKD (KNOW-CKD). After excluding 641 patients who have missing data, a total 1597 patients were included. Alcohol consumption within last 1 year was categorized into none, ≤ 1 drinks/month, 2-4 drinks/month, 2-3 drinks/week, and ≥ 4 drinks/week. Primary outcome was a composite of halving of eGFR or the onset of ESRD.

Results

The mean age was 53.5 years and 61.6% were male. Patients with decreased renal function were less likely to consume alcohol (P for trend < 0.001). There was a significant interaction between alcohol consumption and eGFR (p < 0.001). During a median follow-up of 38.1 months, primary outcome occurred in 263 (16.5%) patients. In a multivariate Cox regression after adjustment of age, sex, BMI, SBP, CRP, total cholesterol, smoking and CCI score, more alcohol consumption was significantly associated with a lower risk for adverse outcome. Compared to non-drinkers, hazard ratios (HRs) for developing primary renal outcome who consumed 2-4 drinks/month, 2-3 drinks/week, ≥ 4 drinks/week were 0.67 (95% confidence interval [CI], 0.47-0.97; p=0.034), 0.59 (95% CI, 0.37-0.95; p=0.031) and 0.29 (95% CI, 0.11-0.79; p=0.015), respectively. However, beneficial effect of alcohol was lost after eGFR, urine protein-creatinine ratio, and hemoglobin were added to the model.

Conclusion

We demonstrated no association between alcohol consumption and renal adverse outcomes after adjustment of CKD-related factors. Thus, beneficial effects of alcohol on CKD progression should be interpreted cautiously with CKD severity taken into account.