Abstract: SA-PO182

Different Measures of Dietary Protein Intake and Correlations with Laboratory Markers across Race in Hemodialysis Patients

Session Information

Category: Nutrition, Inflammation, and Metabolism

  • 1401 Nutrition, Inflammation, Metabolism

Authors

  • Hsiung, Jui-Ting, UC Irvine, Orange, California, United States
  • Streja, Elani, UC Irvine, Orange, California, United States
  • Soohoo, Melissa, UC Irvine, Orange, California, United States
  • Rhee, Connie, UC Irvine, Orange, California, United States
  • Kalantar-Zadeh, Kamyar, UC Irvine, Orange, California, United States
Background

Clinical practice guidelines recommend higher protein intake in hemodialysis (HD) patients, given their heightened risk of protein catabolism and protein energy wasting. Little is known how different components of protein intake correlate with laboratory markers, and whether this differs by race/ethnicity.

Methods

We examined HD patients from three prospective studies, the Anti-Inflammatory and Anti-Oxidative Nutrition in Hypoalbuminemic Dialysis Patients (AIONID), Nutritional and Inflammatory Evaluation in Dialysis (NIED), and Fosrenal for Enhancing Dietary Protein Intake in Hypoalbuminemic Dialysis Patients (FrEDI). We analyzed the correlations of dietary protein (total, animal, and vegetable) ascertained by three-day dietary record with laboratory measures including normalized protein catabolic rate (nPCR), serum albumin, and serum bicarbonate (CO2) stratified by race/ethnicity.

Results

The cohort was comprised of 336 HD patients, among whom 46% and 37% of patients were Hispanic White and African-American, respectively, 48% of patients were female and the mean±SD age was 55±14 years. In the overall cohort, nPCR strongly correlated with total protein (r=0.25, p<0.001) and animal protein (r=0.25, p<0.001), as well as within strata of African American, Caucasian, and Hispanic patients. However, there was no correlation between nPCR and vegetable protein (r=0.07, p=0.22) in any of the racial/ethnic groups. Serum albumin and CO2 showed weaker correlations with total protein, animal protein, and vegetable protein across all patients.

Conclusion

These findings suggest that nPCR has a stronger correlation with total and animal protein intake than with serum albumin and CO2 across all racial/ethnic groups. Further studies are needed to determine whether nPCR may be a more accurate tool for monitoring dietary protein among HD patients in the clinical setting.

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Funding

  • NIDDK Support