Abstract: TH-PO665
Effect of Glomerulus Endocapillary Proliferation Lesion on the Heavy Proteinuria in Children with HSPN
Session Information
- Pediatric Nephrology
November 02, 2017 | Location: Hall H, Morial Convention Center
Abstract Time: 10:00 AM - 10:00 AM
Category: Developmental Biology and Inherited Kidney Diseases
- 403 Pediatric Nephrology
Authors
- Huang, Yanjie, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China
- Liu, Xia, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China
Background
To analyse whether glomerulus endocapillary proliferation lesion is one of important pathologic factors in HSPN and its influence on high and medium molecular weight proteins in urine.
Methods
The pathological features of 148 children HSPN with heavy proteinuria were investigated retrospectively. The means of 24h proteinuria and urinary IgG, transferrin and albumin were detected using immunonephelometry method. The correlation between endocapillary proliferation lesion and 24h proteinuria, urinary IgG, transferrin and albumin were analyzed respectively.
Results
Of 581 cases of HSPN who underwent renal biopsy, 148 cases of HSPN accompanied by heavy proteinuria accounted for 25.47%. Pathological types of HSPN accompanied by heavy proteinuria included IIb, IIIb, IIIb and endocapillary proliferation, IVb, and pure endocapillary proliferation type. Among these types, pure endocapillary proliferation type accounted for 7.43%. The value of 24h proteinuria and urine albumin quantitation in endocapillary proliferation type HSPN were higher than other pathological types, and the percentage of endocapillary proliferation is correlated positively with 24h proteinuria and urine albumin quantitation.
Conclusion
The pathological type of HSPN with heavy proteinuria is diversity. Glomerulus endocapillary proliferation is one of the important pathological factor of HSPN heavy proteinuria, and albumin is major urine protein composition.
Funding
- Government Support - Non-U.S.