Abstract: TH-PO013

An Association of Renal Arteriolopathy with Combination of Hypertriglyceridemia and Increased Serum Complement Component 3 in CKD

Session Information

Category: Chronic Kidney Disease (Non-Dialysis)

  • 301 CKD: Risk Factors for Incidence and Progression

Authors

  • Fukuhara, Chisato, University of the Ryukyus, Nishihara-cho, Japan
  • Zamami, Ryo, University of the Ryukyus, Nishihara-cho, Japan
  • Miyagi, Tsuyoshi, University of the Ryukyus, Nishihara-cho, Japan
  • Yamazato, Masanobu, University of the Ryukyus, Nishihara-cho, Japan
  • Ishida, Akio, University of the Ryukyus, Nishihara-cho, Japan
  • Kohagura, Kentaro, University of the Ryukyus, Nishihara-cho, Japan
  • Ohya, Yusuke, University of the Ryukyus, Nishihara-cho, Japan
Background

Metabolic syndrome, which is characterized by adiposity, is a risk factor for progression of chronic kidney disease (CKD). Complement component 3 (C3), one of adipocytokines correlated with serum triglyceride (TG) levels. We previously reported that combination of hypertrigriceridemia (hTG) and increased serum C3 related to proteinuria via unknown mechanism. Arteriolar hyalinosis may relate to proteinuria via disrupted autoregulation of glomerular hemodynamics. In the present study, we examined the association between this combination and renal arteriolopathy, oxidative stress and inflammation in patients with CKD.

Methods

A total of 139 patients with non-nephrotic CKD who underwent renal biopsy were enrolled in this study. Renal arteriolar hyalinosis was semi-quantitatively assessed via arteriole grading. Oxidative stress and inflammation was assessed by d-ROMs (Diacron-Reactive Oxygen Metabolites) test that mainly evaluating the level of hydroperoxides and high-sensitivity C-reactive protein (hs-CRP), respectively. We examined a cross-sectional association between arteriolar hyalinosis and clinical factors such as serum TG and C3 . To evaluate the effect of the combination of hTG and high C3, patients were divided into four groups based on the presence of hTG and high C3 levels (hC3), defined as equal or higher than their median values.

Results

The mean values for age, estimated glomerular filtration rate (eGFR), serum TG and C3 were as follows: 44 years, 74 ml/min/1.73m2, 169 mg/dl and 106. Serum TG, but not C3 was significantly correlated with arteriolar hyalinosis index. Subgroup analysis showed that hTG+/ hC3+ group was characterized by higher levels of body mass index, urine protein, hs-CRP and dROMs. In multivariate regression analysis, hTG+/hC3+ as well as age, systolic blood pressure and HbA1c was positively associated with arteriolar hyalinosis.

Conclusion

These findings suggest that coexistence of hTG and hC3 may relate enhanced oxidative stress and inflammation, which may cause proteinuria in association with arteriolosclerosis.