Kidney Week

Abstract: FR-PO451

Even Overweight Relates to Proteinuria Accompanied with Glomerular Hypertrophy in Non-Nephrotic CKD

Session Information

• CKD: Risk Factors for Incidence and Progression - II
  November 03, 2017 | Location: Hall H, Morial Convention Center
  Abstract Time: 10:00 AM - 10:00 AM

Category: Chronic Kidney Disease (Non-Dialysis)

• 301 CKD: Risk Factors for Incidence and Progression

Authors

• Zamami, Ryo, University of the Ryukyus, Nishihara-cho, Japan

Ryo Zamami,

• Miyagi, Tsuyoshi, University of the Ryukyus, Nishihara-cho, Japan

Tsuyoshi Miyagi,

• Kohagura, Kentaro, University of the Ryukyus, Nishihara-cho, Japan

Kentaro Kohagura,

• Fukuhara, Chisato, University of the Ryukyus, Nishihara-cho, Japan

Chisato Fukuhara,

• Yamazato, Masanobu, University of the Ryukyus, Nishihara-cho, Japan

Masanobu Yamazato,

• Ishida, Akio, University of the Ryukyus, Nishihara-cho, Japan

Akio Ishida,

• Ohya, Yusuke, University of the Ryukyus, Nishihara-cho, Japan

Yusuke Ohya,

Background

Glomerular hypertrophy (GH), a potential marker for glomerular hypertension is suggested to relate progression of chronic kidney disease (CKD). However, risk factors for GH are not clear. Thus, we conducted cross sectional study to elucidate clinical factors, which relate to the presence of GH among CKD patients.

Methods

A total of 107 patients with non-nephrotic CKD who underwent renal biopsy were recruited. The glomerular diameter of the biopsy specimen was measured. We compared clinical characteristics between the patients with GH and those without it, which defined as equal or larger than the 75th percentile value of glomerular diameter.

Results

The mean value for age, estimated glomerular filtration rate (eGFR), and body mass index (BMI) were as follows: 40 years, 86 ml/min/1.73m² and 24.0 kg/m². The median (quartile range) of maximal GD was 219 (202 – 245) mm, and the 75th percentile value was 245 mm. The group with GH had higher proportion of male and higher value of BMI, systolic blood pressure, uric acid and triglyceride. There was positive correlation between glomerular diameter and BMI. In the multivariate logistic regression analysis, overweight (BMI ≥ 25 kg/m²) was significantly associated with GH (odds ratio 4.66, 95% confidence interval 1.33–16.3, P=0.02) independent of age, sex and some confounding factors such as diabetes mellitus. In the overweigh patients, glomerular diameter was significantly correlated with urine protein (r=0.52, P=0.0007).

Conclusion

Overweight is an independent determinant for glomerular hypertrophy. Even overweight may be a risk factor for progression of CKD in association with GH.