Abstract: SA-PO173

The Effect of Selenium Deficiency on Thyroid Function and Cardiovascular Diseases in Peritoneal Dialysis Patients

Session Information

Category: Nutrition, Inflammation, and Metabolism

  • 1401 Nutrition, Inflammation, Metabolism

Authors

  • Cho, Jong tae, Dankook University Hospital, Dankook University, College of Medicine, Cheonan, Chungnam, Korea (the Republic of)
  • Kim, So Mi, Dankook University Hospital, Dankook University, College of Medicine, Cheonan, Chungnam, Korea (the Republic of)
  • Lee, Eun kyoung, Dankook University Hospital, Dankook University, College of Medicine, Cheonan, Chungnam, Korea (the Republic of)
  • Park, Chang hyun, Dankook University Hospital, Dankook University, College of Medicine, Cheonan, Chungnam, Korea (the Republic of)
  • Jeon, Jihyen, Dankook University Hospital, Dankook University, College of Medicine, Cheonan, Chungnam, Korea (the Republic of)
Background

Trace element, selenium deficiency is known to be associated with impairment of thyroid hormone, and it can cause cardiovascular diseases, such as ischemic heart disease (IHD), heart failure (HF) or cardiomyopathy. In peritoneal dialysis (PD) patients, various causes may contribute to selenium deficiency, including dietary restriction, malabsorption, alteration of metabolism, and removal through dialysis itself. Therefore, we tried to investigate the effect of selenium deficiency on thyroid hormone and cardiovascular diseases in PD patients

Methods

This cross-sectional study enrolled 86 end-stage renal disease patients who underwent PD. The patients were divided into 2 groups based on serum seleium levels : 62 patients were normal level and 22 patients were selenium deficient. Thyroid hormones, including TSH, free T4 were measured. And presence of cardiovascular diseases, using echocardiography, coronary computed tomography or coronary angiography were evaluated.

Results

There were no significant differences in baseline characteristics, including age, sex, presence of diabetes mellitus, duration of PD and weekly Kt/V between the two groups. Although there was no significant difference, thyroid hormone impairment showed higher tendency in selenium deficient group than that in non- selenium deficient group ( 25 % vs 10 % p=0.06 ). The prevalence of IHD was significantly higher in selenium deficient group than that in the non-selenium deficient group ( 55 % vs 21 %, p=0.04 ). But, there was no difference in HF defined as ejection fraction with below 40 %, and cardiomyopathy between the two groups. All patients with thyroid hormone impairment showed high prevalence of IHD and the coincidence of thyroid impairment and IHD was significantly higher than that in selenium deficient group than that in non-selenium deficient group ( 63 % vs 31 %, p=0.01 ).

Conclusion

This study showed higher prevalence of thyroid hormone impairment and IHD in PD patients with selenium deficiency. Selenium deficiency may be related to thyroid hormone impairment, leading to cardiovascular diseases.