Abstract: TH-PO962

Long-Term Neurodevelopmental and Anthropometrical Outcome of Children Born to Female Kidney Transplant Recipients

Session Information

Category: Transplantation

  • 1702 Transplantation: Clinical and Translational

Authors

  • Haninger, Natalja, Medical University of Vienna, Vienna, Austria
  • Vacariu, Apostolos, Medical University of Vienna, Vienna, Austria
  • Schmidt, Alice, Medical University of Vienna, Vienna, Austria
  • Sunder-Plassmann, Gere, Medical University of Vienna, Vienna, Austria
Background

Pregnancy rates have increased during the last years among kidney transplant recipients and live birth rate is high. These pregnancies are deemed high risk, with many obstetric complications and negative delivery outcomes. No long-term data of neurodevelopmental and anthropometrical outcome in this high risk population are available.

Methods

We retrospectively analyzed neurodevelopmental and anthropometrical long-term outcome data of 36 children born to 29 female kidney transplant recipients between 1989 and 2017. Data were collected from chart reviews (including Bayley Scales of Infant Development, percentile lines by WHO growth charts adjusted to expected height), personal interviews of the mother, and the Austrian Mother Child Booklet.

Results

We evaluated a total of 51 pregnancies. Pre-eclampsia was observed in 5 pregnancies (10%). Live birth rate was 71% (n=36), rate of abortion 29% (n=15), including 2 stillbirths. 34 singletons and one set of twins were born after organ transplantation (19 females, 17 males; 2 singletons after IVF). 83% required C-section, 16 infants were born term, 20 (56%) premature; 16 of them had low birth weight, including 6 with very low and 4 with extremely low birth weight. 11 (31%) were small for gestational age. Mean gestational week at delivery was 35±4. 14 children required neonatal intensive care treatment. One child was born with renal pelvic dilatation (4%).
Mean age of children was 11,3±8,2 years at assessment for physical, social, and psychomotor skills. Growth retardation was seen in 9 children (25%); 5 (14%) were above normal range; 22 (61%) as expected. Hyperactivity disorder (n=2), poor fine motor skills (n=3), delayed speech development or speech abnormalities (n=3), and cognitive developmental disorder (n=1) were diagnosed.

Conclusion

We observed an enhanced rate of neurodevelopmental delay and anthropometrical abnormalities in this high risk population. Obstetric and delivery complications might influence neurodevelopmental and anthropometrical outcome in children born to female kidney transplant recipients.