Abstract: SA-PO276

Improvement of Clinical Outcome in Kidney Diseases via the On-line Thai Glomerular Disease Registry: IgA Nephropathy

Session Information

Category: Glomerular

  • 1005 Clinical Glomerular Disorders

Authors

  • Pichaiwong, Warangkana, RAJAVITHI HOSPITAL, Bangkok, Thailand
  • Chawanasuntorapoj, Ratana, Siriraj Hospital, Bangkok, Thailand
  • Tantranont, Ngoentra, Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • Nimkietkajorn, Veerapatr, Buddhachinaraj hospital, Phitsanulok, Thailand
  • Worawichawong, Suchin, Ramathibodi Hospital, Bangkok, Thailand
  • Kitiyakara, Chagriya, None, Bangkok, BANGKOK, Thailand

Group or Team Name

  • Thai Glomerular Disease Collaborative Network (TGCN)
Background

IgA nephroathy (IgAN) is the most common primary glomerular disease leading the end stage renal disease in Thailand. The data on epidemiology of IgA nephropathy (IgAN) in Thailand are limited. The available data came from few medical schools, which might not represent the entire Thai population. The Thai Glomerular Disease Collaborative Network (TGCN) was established to determine the prevalence, clinical characteristics, outcomes and prognosis in Thai glomerular disease patients.

Methods

The data collected prospectively from TGCN included adult patients with biopsy-proven glomerular disease from institutes in Thailand participating in TGCN from July 2014 to March 2017. The clinical and renal pathology characteristics, treatment regimens at the time of renal biopsy were obtained via online data collection forms.

Results

Among 1,556 patients, the most common renal pathology finding in primary glomerular disease was IgAN with prevalence of 13.5%. At baseline, 44.3% of IgAN patients were male, the mean age was 39.4±13 years, median serum creatinine (sCr) was 1.76 mg/dL (0.56-13.2), median urine protein creatinine ratio (UPCR) was 2.63 g/g.Cr (0.02-21.56), and mean serum albumin (sAlb) was 3.6±0.7 g/dL. Nephritis was the most common presentation account for 48.1%. Most of the patients had high initial sCr at the time of biopsy (sCr > 1.2 mg/dL, 77.5%). Clinically, both systolic and diastolic blood pressure at time of biopsy had the significantly high in patients who had serum creatinine ≥ 3 mg/dL compare to < 3 mg/dL (147±18/88±14 vs. 136±16/84±12 mmHg, p = 0.001 and p= 0.048). Histologically, an analysis of The Oxford Classification of IgAN, interstitial fibrosis/tubular atrophy (T) > 50% had significantly high in patients who had serum creatinine ≥ 3 mg/dL.

Conclusion

Conclusions: The prevalence of IgAN in our study was 13.5%. Two independent factors of severe manifestation at the time of biopsy were high blood pressure and high score of tubulointerstitial involvement. Further follow-up of clinical outcomes is being investigated.

Funding

  • Private Foundation Support