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Abstract: SA-PO697

Effect of Lipo-PGE1 on Peritoneal Transport Function and Micro-Inflammatory State in Peritoneal Dialysis Patients

Session Information

  • Peritoneal Dialysis - II
    November 04, 2017 | Location: Hall H, Morial Convention Center
    Abstract Time: 10:00 AM - 10:00 AM

Category: Dialysis

  • 608 Peritoneal Dialysis

Authors

  • Zhang, Hao, The Third Xiangya Hospital of Central South University, Changsha, HuNan, China
  • Wang, Jianwen, The third Xiangya Hospital of Central South University, Changsha, China
Background

Besides the low molecular weight(LMW) solutes, macromolecule such as proteins can also be transported from plasma to peritoneal cavityin peritoneal dialysis(PD). Prostaglandin E1 incorporated in lipid microspheres (Lipo-PGE1) is a potent vasodilator. It was shown to protect vascular endothelial cellsand inhibit the infiltration of inflammatory cells. The aim of this study was to investigate the effect of Lipo-PGE1 on peritoneal transport function and micro-inflammatory state in PD patients.

Methods

We recruiteda total of 89 CAPD patients in the Third Xiangya Hospital from January 2015 to January 2017. Patients were divided into 2 groups, namely the experimental group (Lipo-PGE1 group,n=46) and the control group (not treated with Lipo-PGE1,n=43). The MTACs of urea and creatinine were regarded astheindexes for the transport of LMW solutes. Peritoneal clearances of β2-microglobulin, cystatin C,and albumin were taken asthe indexes to evaluate peritoneal macromolecule transport. IL-6 appearance rate(AR)in the PD effluent, serumIL-6, and hs-CRP were the inflammatory indicators.

Results

The results in the same group before and after2-week treatment showed that: in the experimental group, peritoneal clearances of β2-microglobulin,cystatin C and albumin increased significantly(P<0.05); IL-6 AR, serum IL-6 and hs-CRP level decreased obviously (P<0.05); The MTACs of urea and creatininehave no statistical significance (P>0.05). In the control group, after 2-week treatment, all above indexes have no statistical significance (P>0.05). Thecomparison between two groups showed that: in the experimental group, peritoneal clearance of β2-microglobulin and cystatin C are significantly higher than that in the control group (P<0.05). Peritoneal clearance of albumin, MTAC urea,and MTAC creatinine are also higher than that in the control group, but with no statistically significant difference (P>0.05). IL-6 AR are obviously lower than that in the control group (P<0.05); Serum IL-6 and hs-CRP are also lower than that in the control group, but with no significant difference (P>0.05).

Conclusion

Lipo-PGE1 significantly increases peritoneal transport of macromolecules. Lipo-PGE1 can decrease inflammatory cytokines IL-6 concentration, and reduce micro-inflammatory state in CAPD patients, especially peritoneal cavity local inflammation response.

Funding

  • Government Support - Non-U.S.