Abstract: TH-PO925

Prevalence of Vitamin D Deficiency after Kidney Transplantation and Its Association with Clinical Outcomes

Session Information

Category: Transplantation

  • 1702 Transplantation: Clinical and Translational

Authors

  • Bedi, Puneet, Montefiore Medical Center, Bronx, New York, United States
  • Hayde, Nicole A., Montefiore Medical Center, Bronx, New York, United States
  • Ajaimy, Maria, Montefiore Medical Center, Bronx, New York, United States
  • Akalin, Enver, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, United States
Background

Kidney transplant recipients usually have low vitamin D levels, especially in the early posttransplantation period. Vitamin D deficiency is recognized as a risk factor for progression of kidney disease in general population. However, its association with graft outcomes in renal transplant patients is not well established.

Methods

We measured 25-hydroxyvitamin (OH) D levels and intact-Parathyroid hormone (i-PTH) levels at 6, 12, 24 and 36 months post-transplant in patients transplanted at our center between Jan 2009 and Dec 2014 and measured the association between 6 month post-transplant 25-OH-vit D and i-PTH levels and clinical outcomes.

Results

Prevalence of 25-OH-vit D levels <15, 15-19.9, 20-29.9, and > 30 ng/ml, was (29.2%, 22.2%, 34.7%, 13.3%) at 6 months, (21.4%, 23.7%, 35.0%, and 19.7%) at 1 year, (14.9%, 21.9%, 41.3%, 21.8%) at 2 years, and (16.8%, 18.5%, 38.5%, 26.2%) at 3 years, respectively. A total of 383 patients were followed up for 3.8 (2.4-5.3) years. There was no difference between the 4 groups in terms of age, sex, race, type of transplant, donor age, donor final creatinine, KDPI score, PRA levels, pretransplant DSA, and type of induction. A negative correlation between 25-OH-vit D and i-PTH levels at 6 months was found to be statistically significant ( P<0.0001). Lower 25-OH-vit D levels did not increase risk of graft loss. Patient survival, incidence of acute antibody or T cell mediated rejection, transplant glomerulopathy, development of de novo DSA, incidence of opportunistic viral (CMV and BKV) and fungal infections, malignancy, proteinuria and serum creatinine levels at 1,2 and 3 years post-transplant were found to be similar in the 4 groups.

Conclusion

25-OH-vit D deficiency is common after kidney transplantation and has a negative correlation with post-transplant i-PTH levels. Low 6 months post renal transplant 25-OH-vit D levels are not associated with decreased allograft survival or function or with increased risk for opportunistic infections/malignancy.