Abstract: FR-PO737

The Relationship between Immunological Activity Markers and the Presence of Crescents in Renal Biopsy in Patients with Lupus Nephritis

Session Information

Category: Glomerular

  • 1004 Clinical/Diagnostic Renal Pathology and Lab Medicine

Authors

  • Kanclerz, Katarzyna, Medical University of Gdansk, Gdansk, Poland
  • Komorniczak, Michal, Medical University of Gdansk, Gdansk, Poland
  • Bullo-Piontecka, Barbara, Medical University of Gdansk, Gdansk, Poland
  • Perkowska-Ptasinska, Agnieszka, Transplantation Institute, Medical University of Warsaw, Warsaw, Poland
  • Debska-Slizien, Alicja, Medical University of Gdansk, Gdansk, Poland
Background


Among lupus nephritis (LN) patients (pts) various forms of crescents can be observed in the majority of glomeruli in renal biopsy.
The objective of the study was to assess the relationship between the presence of crescents in renal biopsy and levels of immunological activity markers in LN pts.

Methods


The study group consisted of 29 W and 8 M, mean age 35.43 ± 11.22 years (range 18-66,) with biopsy proven LN. Anti-dsDNA and anti-C1q antibodies, complement component 3 (C3) and complement component 4 (C4), IgG concentrations and circulating immune complexes (C1q and C3d) represent the markers of immunological activity of the disease. Percentage of cellular crescents and percentage of all types (cellular, fibrous, fibrocellular) of crescents were evaluated in renal biopsy.

Results


The study revealed a statistically significant correlation between the percentage of all crescent types with the serum C3 level (r=-0.50; p=0.002) and anti-dsDNA antibodies (r=0.40; p=0.015). Furthermore, a substantial negative relationship between all types of cellular crescents with C3 (r=-0.55; p=0.002) and the IgG concentration (r=-0.34; p=0.039) was noted. However, no statistically important interrelation between the presence of renal crescents and anti-C1q antibodies of circulating immune complexes was found.

Conclusion


Activity of LN, evaluated using immunological markers (including a low level of C3 and a high level of anti-dsDNA), corresponds with a more aggressive form of nephropathy, associated with numerous crescents in renal biopsy.