Abstract: FR-PO565

Cardiovascular Risk in Healthy Subjects Evaluated with Clinical-Genetic Test and Carotid Echography

Session Information

Category: Hypertension

  • 1102 Hypertension: Basic and Experimental - Renal Causes and Consequences

Authors

  • Lavilla, Francisco javier, Clinica Universidad de Navarra, Pamplona, Spain
  • Errasti, Pedro, Clinica Universidad de Navarra, Pamplona, Spain
  • Alfaro Sanchez, Christian Israel, Clinica Universidad de Navarra, Pamplona, Spain
  • Garcia-Fernandez, Nuria, Clinica Universidad de Navarra, Pamplona, Spain
  • Fdez-Felechosa, Pelayo Moiron, Clinica Universidad de Navarra, Pamplona, Spain
  • Mora gutierrez, Jose maria, Clinica Universidad de Navarra, Pamplona, Spain
Background

Evaluate cardiovascular risk (CVR) in healthy patients with clinical genetic test (Cardio inCode® test), and carotid echography.

Methods

cohort of 94 subjects (médium age 53 years 0.911, and male 73.5) We evaluate CVR with genetic test (Cardio inCode® that evaluated cardiovascular age -CVAGE- and global cardiovascular risk -GCVR-, using validated clinical and genetic score) and with carotid echography (intima.media thickness in left –IMTLC- and right -IMTRC- carotid). We evaluate levels of Glucose, Triglycerides, Total, HDL and LDL cholesterol, uric acid, creatinine (mg/dL) and creatinine clearance (ml/min) (MDRD-4 and CKD-EPI). We calculated the difference between cardiovascular (CVAGE) and biological age SPSS 20.0.

Results

Markers of CVR measure with Cardio inCode are associated with carotid and analytical parameters:
Carotid: IMTLC is associated with AGE (r: 0.499, p: 0.001), CVAGE (r: 0.588, p= 0.001) and GCVR (r: 0.492, p: 0.001). IMTRC with AGE (r: 0.493, p: 0.001) , CVAGE (r: 0.511, p= 0.001) and GCVR (r: 0.398, p: 0.001).
Renal function:CKD-EPI is associated with AGE (r: -0.364, p: 0.001) and CVAGE (r: -0.361, p= 0.001) but MDRD not.
Metabolic parameters: GLUCOSE is associated with CVAGE (r: 0.272, p= 0.008) ,GCVR (r: 0.224, p: 0.031), IMTLC (r: 0.254, p= 0.020) ,IMTRC (r: 0.214, p: 0.051) TG with CVAGE (r: 0.360, p= 0.001) ,GCVR (r: 0.453, p: 0.001), IMTLC (r: 0.400, p= 0.001) ,IMTRC (r: 0.241, p: 0.027) URIC ACID with CVAGE (r: 0.376, p= 0.001) ,GCVR (r: 0.353, p: 0.001) and IMTLC (r: 0.242, p= 0.001).
Differences between CVAGE and biological age is associated with IMTLC (r:0.294, p: 0.007) and GCVR (r:0.363, p: 0.001). In 31.3% this difference is more than 10 years. No differences in biological age in this group.

Conclusion

Intima media thickness in left carotid is a good marker and better than in right carotid to evaluate CVR. CKD-EPI are better associated with CVR and Cardio inCode® than MDRD. Metabolic parameters (except cholesterol) are associated with Cardio inCode and intima media thickness. Difference between CVAGE and biological age are associated with cardiovascular risk. This difference depends on CVR, not biological age. In healthy subjects we can evaluated CVR with Cardio inCode® and carotid echography.