Abstract: FR-OR116
CKDu in Mexico: The Case of Poncitlán, Jalisco
Session Information
- The Slow Burn: CKD Risk Factors for Incidence and Progression
November 03, 2017 | Location: Room 395, Morial Convention Center
Abstract Time: 04:42 PM - 04:54 PM
Category: Chronic Kidney Disease (Non-Dialysis)
- 301 CKD: Risk Factors for Incidence and Progression
Authors
- Garcia-Garcia, Guillermo, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
- Morraz Mej?a, Evelyn Fabiola, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
- Montalban, José Manuel, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
- Chavez, Jonathan, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
- Vazquez martinez, Luz E, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
- Pacheco, Eduardo Nungaray, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
- Renoirte, Karina, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
Background
An elevated prevalence of CKD of unspecified cause (CKDu) has been documented in various developing countries. It has been reported by the media a high prevalence of CKDu in towns located by Chapala Lake, Mexico, particularly in the communities of San Pedro Itzican, Agua Caliente, and Mezcala, in Poncitlan, Mexico. Environmental factors have been blamed as the probable cause of the pandemia.
Methods
Since 2006, we pioneered screening people at risk for the presence of CKD using mobile units that travel to rural and urban communities of Jalisco. Trained personnel collected demographic and clinical data, and obtained blood and urine for serum chemistry and dipstick urinalysis. Those individuals who were aware they had kidney disease were not assessed; all others were eligible to participate. GFR was estimated with the MDRD formula. CKD was defined as an eGFR < 60 ml/min/1.73m2.
Results
Between 2007-2016, 50,909 adults were screened with the mobile units. Findings in individuals residing in Poncitlan were compared with those living in other Jalisco municipalities (Table)
Conclusion
CKD and proteinuria were highly prevalent among individuals living in communities of Poncitlan, Mexico. CKD prevalence was two-fold higher among the adult population in comparison with other Jalisco municipalities. Prevalence of proteinuria was three-fold higher than in other communities of Jalisco. Undergoing studies will provide information on the causes of this epidemic
Results
| All n=50,909 | Poncitlan n=283 | Other municipalities n= 50,626 | p | |
| Age, y | 52.33±14.82 | 50.92±17.16 | 52.32±14.80 | 0.173 |
| Male, % | 32.0 | 21.9 | 32.1 | 0.000 |
| Known DM, % | 22.5 | 15.9 | 22.5 | 0.03 |
| Known HTN, % | 32.7 | 26.9 | 32.7 | 0.113 |
| SBP ≥ 140, % | 39.5 | 47.9 | 39.4 | 0.005 |
| DBP ≥ 90 , % | 20.4 | 20.7 | 20.4 | 0.888 |
| % with IMC ≥ 30 | 35.4 | 26.8 | 35.4 | 0.001 |
| % with eGFR < 60 ml/min/1.73 m2 | 10.6 | 20.1 | 10.4 | 0.002 |
| % with dipstick + proteinuria | 11.2 | 36.1 | 11.0 | 0.000 |
Funding
- Private Foundation Support