Abstract: FR-PO062

Use of a Serum Creatinine Point of Care Test in Low Resource Settings: Correlation and Agreement with Hospital Based Assessment

Session Information

  • AKI Clinical: Predictors
    November 03, 2017 | Location: Hall H, Morial Convention Center
    Abstract Time: 10:00 AM - 10:00 AM

Category: Acute Kidney Injury

  • 003 AKI: Clinical and Translational

Authors

  • Macedo, Etienne, University of California San Diego Medical Center, San Diego, California, United States
  • Hemmila, Ulla, College of Medicine, Malawi, Kokemäki, Finland
  • Sharma, Sanjib Kumar, B P Koirala Institute of Health Sciences, Dharan, Nepal
  • Claure-Del Granado, Rolando, Universidad Mayor de San Simon, School of Medicine, Cochabamba, Bolivia, Plurinational State of
  • Burdmann, Emmanuel A., University of Sao Paulo Medical School, Sao Paulo, Brazil
  • Rocco, Michael V., Wake Forest School of Medicine, Winston-Salem, North Carolina, United States
  • Cerda, Jorge, Albany Medical College, Albany, New York, United States
  • Mehta, Ravindra L., University of California San Diego Medical Center, San Diego, California, United States
Background

The ISN0by25Pilot Project was designed to evaluate an education and training program coupled with a point of care (POC) serum creatinine (sCR) test and teleconsultation to improve detection and management of AKI in low resource settings. We evaluated in paired samples the correlation between the POC sCR test applied in the health center to the hospital lab sCR results.

Methods

Paired results of sCR POC test and hospital lab values were compared in adults and childre with and without CKD in the 3 clusters (Bolivia, Nepal and Malawi) participating in the project. sCR was measured by Jaffe reaction and the sCR POC test was performed using the StatSensor® Cr Xpress™ Meter.Correlation between lab and POC test was evaluated by Spearman’s test and Bland Altman tests.

Results

We assessed 58 samples collected during clinical care obtained at the same time as the POC test. None of the pts were receiving renal support. Lab sCR values ranged from 0.5-25.9 mg/dl in adults and 0.4-13 mg/dl in children. Overall, correlation between hospital lab assessment and POC test was 0.872, (adults 0.879 and children 0.962) and similar for pts with and without CKD (no CKD 0.817, CKD 0.857); p<0.001. Bland Altman plot (Figure 1) showed a good agreement between the two measurements through the middle range of CR values.

Conclusion

The sCR POC test performed well in adult and children and can be utilized to assess kidney function in health care centers in low resource settings. The good correlation and agreement between the two measurements, suggests that POC test values are probably valuable for pt follow up through their course of illness and to assess kidney function recovery.

Figure 1 – Bland Altman plot showing the differences between laboratory and Xpress values and vs. the mean of the two measurements.

Funding

  • Private Foundation Support