Abstract: SA-PO702
Glucose Metabolism as Part of Metabolic Syndrome in Non-Diabetic PD Patients: Results from PD-CRAFT
Session Information
- Peritoneal Dialysis - II
November 04, 2017 | Location: Hall H, Morial Convention Center
Abstract Time: 10:00 AM - 10:00 AM
Category: Dialysis
- 608 Peritoneal Dialysis
Authors
- Lambie, Mark, Keele University, Crewe, United Kingdom
- Davies, Simon J., Keele University, Crewe, United Kingdom
Background
Dialysate glucose loading has been associated with an increase in metabolic syndrome in ethnically Chinese patients however the impact on other populations is not clear, and neither is the impact on systemic glucose metabolism.
Methods
This was a cohort study of prevalent patients on peritoneal dialysis in 39 centres in the UK. Whole blood samples were stored in the BioCentre and transferred to a central laboratory for glycated haemoglobin assays. Waist circumference was measured with dialysate in situ, and other demographic and clinical measures were stored in a bespoke database (PDDB). Adjusted analysis was by linear regression models, with backwards selection of variables.
Results
628 non-diabetic patients were included but 26 patients with values >8.0% were excluded from further modelling. There was a median glycated haemoglobin of 5.7% (IQR 5.4-6.0). There was no significant correlation between glycated haemoglobin and dialysate glucose load (-0.08). Correlations with individual components of metabolic syndrome were absent/weak (body mass index 0.05, triglycerides 0.09, HDL cholesterol -0.06) apart from waist circumference (0.17). Results for random plasma glucose levels were similar to glycated haemoglobin. In multivariable modelling there was strong evidence for an effect of age, and decreasing strength of evidence for an association with triglycerides, waist circumference and ischaemic heart disease with no evidence for other variables including dialysate glucose load. The multivariable model had an adjusted R-squared value of 0.18. Waist circumference provided a better model than body mass index (Δ-2LL=3.58).
Conclusion
There does not appear to be any significant association between glycated haemoglobin and dialysate glucose load in non-diabetic PD patients. This could be partly because the variability in glycated haemoglobin is poorly explained by other aspects of metabolic syndrome.