Abstract: SA-PO353
CKDu in Mexican Children: The Case of Poncitlan, Jalisco
Session Information
- CKD: Risk Factors for Incidence and Progression - III
November 04, 2017 | Location: Hall H, Morial Convention Center
Abstract Time: 10:00 AM - 10:00 AM
Category: Chronic Kidney Disease (Non-Dialysis)
- 301 CKD: Risk Factors for Incidence and Progression
Authors
- Garcia-Garcia, Guillermo, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
- Rubio, Ricardo, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
- Amador, Melina De jesus, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
- Ibarra-Hernández, Margarita, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
- De la Torre-Campos, Librado, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
- Romero, Alexia Carolina, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
- Navarro blackaller, Guillermo, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
- Rodríguez garcía, Francisco gonzalo, Hospital Civil De Guadalajara, University of Guadalajara, Guadalajara, Mexico
Background
An elevated prevalence of CKD of unspecified cause (CKDu) has been documented in various developing countries. It has been reported by the media a high prevalence of CKDu among children in towns located by Chapala Lake, particularly within the municipality of Poncitlan, Jalisco. Environmental facros have been blamed as the probable cause of the pandemia.
Methods
Since 2006, we pioneered screening people at risk for the presence of CKD using mobile units that travel to rural and urban communities of Jalisco.Trained personnel collected demographic and clinical data, and obtained blood and urine for serum chemistry and dipstick urinalysis. Those individuals who were aware they had kidney disease were not assessed; all others were eligible to participate.GFR was estimated with the Schwartz equation. CKD was defined as an eGFR < 60 ml/min/1.73m2. HTN, malnutrition, and obesity were defined by gender, age, and height specific normative values.
Results
Between 2007-2016, 659 children were screened in the mobile units, 144 of them in the municipality of Poncitlan. Results were compared with those of all other Jalisco municipalities (Table 1)
Conclusion
The prevalence of proteinuria and malnutrition was higher in Poncitlan as compared to other Jalisco municipalities. Undergoing studies will provide information on the posible causes of this high prevalence. Screening programs should be linked to community- and individual-level interventions to reduce the risk of chronic kidney disease in adulthood.
Results
| All n=650 | Poncitlan n=144 | Other municipalities n= 505 | p | |
| Age, y | 13.63±3.92 | 8.78±3.97 | 15.03±2.57 | 0.000 |
| Male, % | 41.4 | 50.0 | 38.8 | 0.01 |
| Known DM, % | 2.9 | 0.0 | 3.8 | |
| Known HTN, % | 1.5 | 0.0 | 2.0 | |
| % with SBP or DBP ≥ 95th percentile | 18.6 | 11.4 | 19.1 | 0.368 |
| % with IMC < 5th percentile | 6.7 | 15.6 | 4.2 | 0.000 |
| % with IMC > 95th percentile | 17.3 | 9.9 | 19.4 | 0.000 |
| % with eGFR < 60 ml/min/1.73 m2 | 2.8 | 0.7 | 3.4 | 0.136 |
| % with dipstick + proteinuria | 16.5 | 44.4 | 4.8 | 0.000 |
Funding
- Private Foundation Support