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Kidney Week

Abstract: SA-PO708

Peritoneal Dialysis Modality Is Independently Associated with Salty Taste Impairment in Patients with ESRD

Session Information

  • Peritoneal Dialysis - II
    November 04, 2017 | Location: Hall H, Morial Convention Center
    Abstract Time: 10:00 AM - 10:00 AM

Category: Dialysis

  • 608 Peritoneal Dialysis

Authors

  • Torigoe, Miki, Nagasaki University Hospital , Nagasaki, Japan
  • Obata, Yoko, Nagasaki University Hospital , Nagasaki, Japan
  • Torigoe, Kenta, Nagasaki University Hospital , Nagasaki, Japan
  • Harada, Takashi, Nagasaki Renal Center, Nagasaki, Japan
  • Funakoshi, Satoshi, Nagasaki Renal Center, Nagasaki, Japan
  • Nishino, Tomoya, Nagasaki University Hospital , Nagasaki, Japan
Background

In chronic kidney disease (CKD) patients, it is reported that the gustatory threshold for salty taste is increased, and its increase is associated with excessive oral salt intake and result in high blood pressure or volume overload. However, little is known about the relationship between the patients with end-stage renal disease (ESRD) requiring renal replacement therapy and the gustatory threshold for salty taste. The aim of this study was to assess the gustatory threshold for salty taste and clarify relevant factors in ESRD patients.

Methods

In this cross-sectional study, we enrolled 29 healthy volunteers and 79 dialysis patients (22 peritoneal dialysis (PD) patients, 57 hemodialysis (HD) patients) in Nagasaki University Hospital and Nagasaki Kidney Center in Japan. For the assessment of gustatory threshold for salty taste, we used a salt-impregnated taste strip, Salsave® (Advantech Tokyo Co, Tokyo, Japan) which are impregnated various salt concentrations (0.6, 0.8, 1.0, 1.2, 1.4 and 1.6 mg/cm2). The clinical data were collected from electronic medical records and we analyzed risk factors of salty taste impairment.

Results

Compared with healthy volunteer, prevalence of salty taste impairment (recognition threshold of salt at ≧1.0 mg/cm2 concentration) was higher in ESRD patients (3% vs 58% p<0.001). Among ESRD patients, rate of PD modality was higher in salty taste impaired group (37.0% vs 15.6% p=0.04). Moreover, in multiple logistic regression adjusting for age, gender, sex, duration of dialysis, serum zinc, C-reactive protein and KT/V, PD modality was independently associated with salty taste impairment (Odds ratio 8.0, 95% confidence intervals 1.1 – 57.4, p=0.04). Among PD patients, the gustatory threshold for salty taste was positively correlated with serum creatinine (ρ=0.44, p=0.04), serum β2-microglobulin (ρ=0.63, p=0.002) and transferrin saturation (ρ=0.50, p=0.02), negatively correlated with 24-hour urine volume (ρ=-0.50, p=0.02) and residual renal KT/V (ρ=-0.55 p=0.01).

Conclusion

This study demonstrated that prevalence of salty taste impairment was higher in ESRD patients, and PD modality was independently high risk of salty taste impairment. Moreover, the gustatory threshold for salty taste was negatively correlated with residual renal function in PD patients.