Abstract: FR-PO748

Clinicopathological Implications of Urinary Soluble CD163 in Glomerulonephritis with Crescentic Formation

Session Information

Category: Glomerular

  • 1004 Clinical/Diagnostic Renal Pathology and Lab Medicine

Authors

  • Yamazaki, Hidenori, The Second Department of Internal Medicine, University of Toyama, Toyama, Japan
  • Koike, Tsutomu, The Second Department of Internal Medicine, University of Toyama, Toyama, Japan
  • Mizutani, Minami, The Second Department of Internal Medicine, University of Toyama, Toyama, Japan
  • Fujioka, Hayato, The Second Department of Internal Medicine, University of Toyama, Toyama, Japan
  • Kakeshita, Kota, The Second Department of Internal Medicine, University of Toyama, Toyama, Japan
  • Kinugawa, Koichiro, The Second Department of Internal Medicine, University of Toyama, Toyama, Japan
Background

M2 macrophages contribute to crescentic formation in various types of glomerulonephritis. A recent report suggested that the level of urinary soluble CD163 (sCD163), a marker of M2 macrophage infiltration, associated very tightly with active renal vasculitis. In this study, the association of urinary sCD163 level with indices of disease activity was analyzed in patients with glomerulonephritis with crescents.

Methods

Subjects were fifty-seven patients with biopsy proven glomerulonephritis with crescentic formation, including microscopic polyangitis (n=14), anti-GBM glomerulonephritis (n=3), IgA vasculitis (n=10), IgA nephropathy (n=22), lupus nephritis (n=6), infectious glomerulonephritis (n=2). In advance of kidney biopsy, measurements of urinary sCD163 and urinary protein excretion (UP), effective glomerular filtration rate (eGFR) were performed.

Results

1) In all subjects, urinary sCD163 correlated positively with the percentage of glomeruli with cellular crescents (r=0.48, p<0.01). In contrast, urinary sCD163 did not associate with the percentage of glomeruli with fibrocellular or fibrous crescents. Additionally, there was a positive correlation between urinary sCD163 and UP (r=0.41, p<0.05), whereas there was no association between urinary sCD163 and eGFR. 2) In thirty subjects followed for six months after immunosuppressive treatments, the positive relationships of urinary sCD163 levels with treatment-induced changes in eGFR (r=0.49, p<0.01) or UP (r=0.41, p<0.05) were observed.

Conclusion

In conclusion, urinary sCD163 may be a novel surrogate marker for disease activity of glomerulonephritis with crescentic formation.