Abstract: TH-PO014

Association of Renal Artery Sclerosis with Serum Complement C3 and Triglyceride–Glucose Index in CKD

Session Information

Category: Chronic Kidney Disease (Non-Dialysis)

  • 301 CKD: Risk Factors for Incidence and Progression

Authors

  • Fukuhara, Chisato, University of the Ryukyus, Nishihara-cho, Japan
  • Miyagi, Tsuyoshi, University of the Ryukyus, Nishihara-cho, Japan
  • Zamami, Ryo, University of the Ryukyus, Nishihara-cho, Japan
  • Yamazato, Masanobu, University of the Ryukyus, Nishihara-cho, Japan
  • Ishida, Akio, University of the Ryukyus, Nishihara-cho, Japan
  • Kohagura, Kentaro, University of the Ryukyus, Nishihara-cho, Japan
  • Ohya, Yusuke, University of the Ryukyus, Nishihara-cho, Japan
Background

An association between serum complement C3 (C3) and renal artery sclerosis has been suggested to exist. We investigated the influence of triglyceride–glucose index (TyG), a marker of insulin resistance, in regard to this association.

Methods

Arteriolosclerosis was semiquantitatively evaluated from hyalinized arterioles of pathological specimens obtained from kidney biopsies, and average scores (grading of arteriole hyalinization) were calculated. Patients with median or higher C3 levels were classified as the high-C3 (HC3) group. TyG was calculated as fasting triglycerides (mg/dL) × fasting glucose (mg/dL) / 2, and patients with median or higher TyG value were classified as the high-TyG (HTyG) group. Patients were then divided into subgroups based on the presence or absence of HC3 and HTyG (HC3−/HTyG−, HC3+/HTyG−, HC3−/HTyG+, and HC3+/HTyG+).

Results

The average score for arteriole hyalinization grading after applying a subgroup-specific logarithmic transformation was significantly higher in the HC3+/HTyG+ group than in the other groups. A multivariate analysis was conducted wherein high degree of arteriole hyalinization (median grade or higher) was the determinant, and age, sex, systolic blood pressure, serum uric acid levels, presence or absence of diabetes, and HC3/HTyG subgroup (Ref: HC3−/HTyG−) were explanatory variables. Results indicated that HC3+/HTyG+ was significant but HC3+/HTyG− was non-significant. The HC3+/HTyG+ group also had the lowest percent flow-mediated dilatation.

Conclusion

An association between C3 and renal artery sclerosis in patients with chronic kidney disease may be prominent in terms of endothelial dysfunction under conditions of high insulin resistance.