Kidney Week

Abstract: FR-PO466

Delayed Renal Recovery and Long-Term Renal Survival after Radical Nephrectomy for Renal Cell Carcinoma

Session Information

• CKD: Risk Factors for Incidence and Progression - II
  November 03, 2017 | Location: Hall H, Morial Convention Center
  Abstract Time: 10:00 AM - 10:00 AM

Category: Chronic Kidney Disease (Non-Dialysis)

• 301 CKD: Risk Factors for Incidence and Progression

Authors

• Park, Hee jung, Gyeongsang national university hospital, Jinju, Jinju-si, Korea (the Republic of)

Hee jung Park,

• Jang, Ha nee, Gyeongsang National Univ. Hospital, Jinju, Korea (the Republic of)

Ha nee Jang,

• Lee, Tae won, Gyeongsang National University Hospital, Jinju-si, Gyeongsangnam-do, Korea (the Republic of)

Tae won Lee,

• Cho, Hyun Seop, Gyeongsang National University Hospital, Jinju-si, Gyeongsangnam-do, Korea (the Republic of)

Hyun Seop Cho,

• Kim, Hyun-Jung, School of Medicine, Gyeongsang National University, Jinju, Korea (the Republic of)

Hyun-Jung Kim,

• Park, Dong Jun, Gyeongsang National University Hospital, Jinju-si, Gyeongsangnam-do, Korea (the Republic of)

Dong Jun Park,

• Bae, Eunjin, Gyeongsang National University Changwon Hospita, Changwon, SEOUL, Korea (the Republic of)

Eunjin Bae,

• Chang, Se-Ho, Gyeongsang national university hospital, Jinju, Jinju-si, Korea (the Republic of)

Se-Ho Chang,

Background

Radical nephrectomy has been associated with chronic kidney disease (CKD). It is unclear whether delayed renal recovery after surgery affects long-term renal outcome.
We investigated the association between delayed renal recovery and long-term renal survival in patients undergoing radical nephrectomy for renal cell carcinoma. We assessed factors affecting the recovery of renal function.

Methods

We reviewed medical record database for all patients (>18 years old) who underwent radical nephrectomy for renal cell carcinoma between from January 2009 to December 2016. Among these, we included patients with a 3-month renal function test after surgery. Renal outcome was defined as a doubling in serum creatinine or End stage renal disease. Estimated GFR were evaluated at baseline, 3 months and the last follow-up. We excluded patients with estimated glomerular filtration rate (GFR) of less than 40 ml/min/1.73m2. Estimated GFR calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. Delayed renal function was defined by creatinine did not decrease less than preoperative value.

Results

Among the 105 patients who met inclusion criteria, 70 (66.7%) were males. The median age at nephrectomy was 62 year (range 25-84 years). 60 (57.1%) were diagnosed with delayed renal recovery: The average serum creatinine was 0.85 ± 0.22 mg/dL, and average estimated GFR was 102.89 ± 29.46 ml/min/1.73m2. The average follow-up period was 39.55 ± 24.48 months.
Multiple linear regression analysis shows delayed renal recovery, baseline estimated GFR to be significantly associated with long-term renal survival (p=0.05, p=0.040, respectively). Hypertension and increased baseline creatinine were the factors affecting early recovery of renal function.

Conclusion

Our results suggest that hypertension and renal impairment for renal cell carcinoma patients may delayed renal recovery after radical nephrectomy, and adversely affect kidney function over a long term period.