Abstract: SA-PO023

Association between Statin Therapy and Occurrence of AKI in Patients with Peripheral Artery Diseases

Session Information

Category: Acute Kidney Injury

  • 003 AKI: Clinical and Translational

Authors

  • Kanai, Daisuke, Nishiwaki Municipal Hospital, Nishiwaki, Japan
  • Nakai, Kentaro, Kakogawa Central City Hospital, Kakogawa, Japan
  • Fujii, Hideki, Kobe University Graduate School of Medicine, Kobe, Japan
  • Nishi, Shinichi, Kobe University Graduate School of Medicine, Kobe, Japan
Background

Acute kidney injury (AKI) is an important clinical problem in diagnosis and treatment of cardiovascular diseases. Though may studies have reported that statin therapy before coronary angiography and/or intervention significantly decreased the occurrence of AKI, the association between pretreatment by statin and occurrence of AKI in patients with peripheral arterial diseases (PAD) remains unclear. Therefore, we researched the association between statin therapy and occurrence of AKI in patients with PAD.

Methods

We retrospectively analyzed data from the endovascular treatment (EVT) database in our hospital. The angiography and/or intervention for PAD were performed for 377 patients between October 2011 and March 2016. Sixty nine hemodialysis patients and 13 patients without sufficient data were excluded from a present study. Remaining 295 patients were enrolled and divided into the two groups; those without statin (control group; N=157) and those with statin (statin group; N=138) for at least one months before admission. AKI was defined by absolute increase in serum creatinine (SCr) of ≥0.5 mg/dl or a relative increase of ≥25% measured 1week after procedure.

Results

Before procedure, sex, SCr, amount of contrast medium, use of renin angiotensin system inhibitor, smoking and blood pressure were similar in both group. The statin group has significantly younger patients, more diabetes patients, higher body mass index (BMI) and lower low density lipoprotein-cholesterol (LDL-C) (100±32 mg/dL vs 108±31 mg/dL) than the control group. As for occurrence of AKI, there was significantly lower incidence in the statin group compared to the control group (5% vs 16%, p<0.05). We performed a multivariate analysis adjusted for age, BMI, diabetes mellitus, LDL-C, SCr and statin therapy. The result of multivariate analysis showed that statin therapy was significantly correlated with the lower occurrence of AKI (p<0.05).

Conclusion

The results of our study suggested that statin therapy may prevent the occurrence of AKI after angiography and/or intervention for PAD.