Kidney Week

Abstract: SA-OR074

Hospitalizations for AKI in Kidney Transplant Recipients in the United States, 2004–2014

Session Information

• Transplant Economics and Live Donor Outcomes
  November 04, 2017 | Location: Room 390, Morial Convention Center
  Abstract Time: 05:06 PM - 05:18 PM

Category: Transplantation

• 1702 Transplantation: Clinical and Translational

Authors

• Singh, Tripti, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States

Tripti Singh, MBBS, MD



• Kumar, Nilay, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States

Nilay Kumar,

• Waheed, Sana, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States

Sana Waheed,

• Djamali, Arjang, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States

Arjang Djamali,

• Garg, Neetika, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States

Neetika Garg,

Background

There is little information on the incidence of acute kidney injury (AKI) and mortality associated with AKI in hospitalized kidney transplant recipients.

Methods

We used the National Inpatient Sample 2004 – 2014 to identify hospitalizations with a primary or secondary diagnosis of AKI in the setting of known history of kidney transplantation. Survey analysis techniques were used to generate national estimates. Linear and logistic regression were used to test trends in outcomes.

Results

There were 36,457 hospitalizations for AKI representative of 176,128 hospitalizations nationally in renal transplant recipients during the study period. Mean age of kidney transplant recipients admitted for AKI was 55.5 years and 43.4% were females. There was a significant increase in the comorbidity burden during the period of study (Charlson comorbidity index 1.3 in 2004 to 2.8 in 2014, p<0.001). There was a nearly threefold increase in hospitalization rate for AKI (52 to 135/1000 transplant recipients, p<0.001) over 10 years. We found a concomitant decline in in-hospital mortality, dialysis requirement and length of stay (LOS) along with a modest but significant negative trend in cost. Utilization for intubation and mechanical ventilation increased during the study period.

Conclusion

Hospitalizations for AKI have increased in the kidney transplant recipients but in-hospital outcomes and resource utilization have improved significantly. Further study is warranted to understand the reasons for increasing rate of hospitalizations for AKI in renal transplant patients.