Abstract: SA-PO270

Chronic HBV Infection Was Associated with Failure to Complete Remission of IgA Nephropathy

Session Information

Category: Glomerular

  • 1005 Clinical Glomerular Disorders

Authors

  • Wu, Haiting, Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences & Peking Union Medical College, Beijing, China
  • Wu, Zhen, Beijing Frendship Hospital, Capital Medical University, Beijing, China
  • Wen, Yubing, Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences & Peking Union Medical College, Beijing, China
  • Cai, Jianfang, Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences & Peking Union Medical College, Beijing, China
  • Li, Hang, Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences & Peking Union Medical College, Beijing, China
  • Li, Xuemei, Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences & Peking Union Medical College, Beijing, China
  • Li, Xuewang, Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences & Peking Union Medical College, Beijing, China
Background

Chronic HBV infection is associated with Glomerulopathies including IgA nephropathy. We conducted a retrospective study to investigate the association between chronic HBV infection and remission of IgA nephropathy.

Methods

In this retrospective cohort, 715 patients with biopsy-proved IgA nephropathy were included, of whom 95 were diagnosed as chronic hepatitis B virus (HBV) infection defined as persistent positivity of hepatitis B virus surface antigen. Data on age, sex, body mass index, presence of hypertension and diabetes mellitus, laboratory tests prior to treatment, and therapeutic regimens were retrospectively retrieved from medical records. Complete remission (CR) was defined as a 24-hour urinary protein <0.3g with a stable estimated glomerular filtration rate (eGFR). Multiple logistic regression analysis was used to estimate the association of HBV infection with CR and a 30% decline in eGFR.

Results

Patients with chronic HBV infection were younger (27.31±35.64 vs 35.64±11.51, P=0.005) and more likely to present heavier proteinuria (3.02±3.44, 2.02±2.18g P < 0.001) and avoid using immunosuppressive agents (10.52%, 58.57%, P < 0.001) as compared with those free of chronic HBV infection. However, the two groups did not differ in baseline eGFR, presence of hypertension and diabetes, administration of RAAS inhibitors and glucocorticoids. In one-year follow-up, HBV infection was associated with failure to CR in proteinuria (OR [95% CI], 2.10 [1.173-3.758], P=0.013), but not with a 30% decline in eGFR(OR [95% CI], OR 1.192 [0.438-3.249], P=0.731), independently of gender, age, diabetes, hypertension, baseline eGFR, 24-hour urinary protein, use of glucocorticoids, immunosuppressive agents and RAAS inhibitors.

Conclusion

Chronic HBV infection may be associatited with failure to complete remission of IgA nephropathy.