Abstract: TH-PO410

Factors Affecting Plasma Linoleic Acid in CKD

Session Information

Category: Nutrition, Inflammation, and Metabolism

  • 1401 Nutrition, Inflammation, Metabolism

Authors

  • Sikorska-Wisniewska, Malgorzata, Medical University of Gdansk, Gdansk, Poland
  • Mika, Adriana, University of Gdansk, Gdansk, Poland
  • Sledzinski, Tomasz, Medical University of Gdansk, Gdansk, Poland
  • Debska-Slizien, Alicja, Medical University of Gdansk, Gdansk, Poland
  • Chmielewski, Michal, Medical University of Gdansk, Gdansk, Poland
Background

Previous studies have shown that plasma linoleic acid (LA, 18:2n-6) is inversely associated with inflammatory markers and all-cause mortality in dialysis patients. The purpose of the present evaluation was to assess plasma LA percentage content in chronic kidney disease (CKD) subjects, and to evaluate factors that could affect it.

Methods

The study included a cohort of 224 participants, comprised of a group of controls free from any kidney disease (n=54), CKD stage 3-5 patients (n=86), dialysis subjects (n=60), and transplanted patients (n=24). LA amount was analyzed by gas chromatography with a mass spectrometer detector, and expressed as percentage of total fatty acids of serum lipids. Intake of products rich in LA (nuts, seeds) was evaluated with a validated FFA-6 questionnaire.

Results

LA content decreased with CKD, as it equalled 26.2 ± 0.5% in controls, 24.2 ± 0.4% in CKD stage 3-5 patients, 22.6 ± 0.5% in dialysis subjects, and 24.2 ± 0.8 in kidney transplant recipients (ANOVA F = 7.75; p<0.001). As in previous studies, chronic inflammation, defined here as a persistently elevated hsCRP > 5 mg/L, was associated with decreased plasma LA, as compared to the group with hsCRP within the normal range (22.7 ± 3.6% vs. 25.1 ± 4.1%; p < 0.001). LA content was also inversely correlated with age and BMI. Ingestion of nuts and seeds showed a considerable linear relationship with the plasma LA content (Sperman rho = 0.22; p<0.05). Nevertheless, CKD turned out as an independent predictor of serum LA content, following adjustment for the abovementioned confounders (adjusted R2 = 0.19; p<0.01).

Conclusion

Serum LA content is decreased in the course of CKD. Taking into account the potential impact of low LA on mortality, increased intake of products reach in this essential fatty acid could be of benefit for CKD patients.

Funding

  • Government Support - Non-U.S.