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Abstract: SA-PO724

Optimal Dwell Time for Maximal Small Solute Clearances in Peritoneal Dialysis Patients

Session Information

  • Peritoneal Dialysis - II
    November 04, 2017 | Location: Hall H, Morial Convention Center
    Abstract Time: 10:00 AM - 10:00 AM

Category: Dialysis

  • 608 Peritoneal Dialysis

Author

  • Sritippayawan, Suchai, Division of Nephrology, Internal Medicine, Siriraj Hospital, Bangkok, Thailand
Background

The adequacy of peritoneal dialysis was assessed by urea and creatinine clearances which depend on daily dialysate volume and dwell time. The objective of this study was to identify the optimal dwell time producing maximal small solute clearances in peritoneal dialysis patients.

Methods

Prospective cohort study was performed in chronic peritoneal dialysis patients at Siriraj hospital. We compared small solute clearances at 9 dwell time periods (0, 5, 10, 15, 20, 30, 40, 50 and 60 minutes). Weekly KT/V urea and weekly nCCr were obtained to identify the optimal dwell time which produced maximal small solute clearances. We also compared rate of glucose absorption, ultrafiltration and other small solute removals such as sodium, potassium, calcium, phosphorus and uric acid at each dwell time period.

Results

Twenty-two peritoneal dialysis patients were enrolled. The 20 minutes of dwell time had maximal weekly KT/V urea (5.01; p < 0.001), weekly nCCr (104.95 L/1.73m2; p 0.018) and potassium removal (78.17 mEq/day; p 0.002). Maximal sodium removal was observed at 0 minutes (394.56 mEq/day; p 0.005). There were no significance different of glucose absorption, ultrafiltration rate and other small solute removal (phosphorus, uric acid and calcium) at any periods of dwell time. Small solute clearances, ultrafiltration and solute removals were not associated with the peritoneal membrane transport types.

Conclusion

20-minutes dwell time had the highest weekly KT/V urea and weekly nCCr in chronic peritoneal dialysis patients. Small solute clearances were not associated with the peritoneal membrane transport types in each short dwell time period.

Funding

  • Government Support - Non-U.S.