Abstract: SA-PO728
Higher Serum Magnesium Is Associated with Lower Abdominal Aortic Calcification Burden in Peritoneal Dialysis (PD) Patients
Session Information
- Peritoneal Dialysis - II
November 04, 2017 | Location: Hall H, Morial Convention Center
Abstract Time: 10:00 AM - 10:00 AM
Category: Dialysis
- 608 Peritoneal Dialysis
Authors
- Stylianou, Kostas, University Hospital of Heraklion, Heraklion, Greece
- Bacharaki, Dimitra, Attikon University Hospital, Athens, Greece
- Balafa, Olga, University Hispital of Ioannina, Ioannins, Greece
- Lygerou, Dimitra, University Hospital of Heraklion, Heraklion, Greece
- Dermitzaki, Eleftheria-Kleio, University Hospital of Heraklion, Heraklion, Greece
- Georgoulidou, Anastasia K, GENERAL HOSPITAL OF KOMOTINI, Komotini, Greece
- Tsirpanlis, George I., "G.Gennimatas" General Hospital, Athens, Greece
- Theodoridis, Marios, University Hospital of Alexandroupolis, Alexandroupolis, Greece
- Mavromatidis, Konstantinos S, GENERAL HOSPITAL OF KOMOTINI, Komotini, Greece
- Kyriazis, Periklis Panos, Beth israel Deaconess Medical Center, Brookline, Massachusetts, United States
- Passadakis, Ploumis, University Hospital of Alexandroupolis, Alexandroupolis, Greece
- Vlahakos, Dimitrios V., Attikon University Hospital, Athens, Greece
Background
To identify factors potentially capable of preventing the progression of abdominal aortic calcification (AAC), a surrogate of cardiovascular risk in PD patients
Methods
95 stable PD patients were studied (52 men), with a mean age of 62±15 years and a median dialysis vintage of 43 (IQR 28-71) months. The AAC was evaluated with Leena Kauppila (LK) score (range 0-24) on plain lateral abdominal radiographs. Patients were divided in a Low calcification score (CS) group: (LK score 0-4) and a High CS group: (LK score 5-24,), each comprising 38 (40%) and 57(60%) patients, respectively. Univariate and multivariate regression analysis were used to determine factors associated with a High CS.
Results
Mean CS in the whole group was 6.95±6.3. Patients with a High CS (10.8±5.1) were older, had a higher prevalence of diabetes (38.6 vs. 17.6%; p=0.04) and peripheral vascular disease (PVD) (29.8 vs. 10.5%; p=0.02), higher pulse pressure (PP) (57±14 vs. 51±15 mmHg; p=0.037) and malnutrition inflammation score (MIS) (5.12±3.1 vs. 3.8 ±2.7; p=0.039, lower serum magnesium (sMg) levels (2.12±0.36; vs. 2.37±0.54; p=0.008) and less use of cinacalcet (19.3 vs. 39.5%; p<0.03). In a multivariate analysis every 1mg/dl increase in sMg was associated with 74% lower odds of having a High CS (Table 1). MIS also emerged as a significant predictor of a high CS (Table 1). sMg was significantly (r=0.31; p=0.002) correlated with dialysate Mg concentration (0.50/0.25 mmol/L)
Conclusion
Our data indicate that sustaining higher sMg levels, as by using higher Mg dialysate concentration, and correcting the malnutrition and inflammation complex syndrome may potentially lower the AAC burden and, thus, improve cardiovascular risk in PD patients
Table 1
| UNIVARIATE | MULTIVARIATE | |||
| OR (95%CI) | P | OR (95%CI) | P | |
| Age (↑1 yr) | 1.08 (1.04–1.1) | <0.001 | 1.055 (1.009–1.1) | 0.018 |
| Diabetes | 2.9 (1.007–8.5) | 0.048 | ||
| PVD | 3.6 (1.1–11.7) | 0.033 | ||
| PP (↑1 mmHg) | 1.03 (1001-1.06) | 0.04 | ||
| MIS (↑1 point) | 1.18 (1.004–1.37) | 0.04 | 1.25 (1.02–1.52) | 0.027 |
| sMg (↑1mg/dl) | 0.28 (0.103–0.74) | 0.01 | 0.26 (0.07-0.94) | 0.04 |
| Cinacalcet | 0.36 (0.14–0.92) | 0.04 |
Funding
- Clinical Revenue Support