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Abstract: SA-PO728

Higher Serum Magnesium Is Associated with Lower Abdominal Aortic Calcification Burden in Peritoneal Dialysis (PD) Patients

Session Information

  • Peritoneal Dialysis - II
    November 04, 2017 | Location: Hall H, Morial Convention Center
    Abstract Time: 10:00 AM - 10:00 AM

Category: Dialysis

  • 608 Peritoneal Dialysis

Authors

  • Stylianou, Kostas, University Hospital of Heraklion, Heraklion, Greece
  • Bacharaki, Dimitra, Attikon University Hospital, Athens, Greece
  • Balafa, Olga, University Hispital of Ioannina, Ioannins, Greece
  • Lygerou, Dimitra, University Hospital of Heraklion, Heraklion, Greece
  • Dermitzaki, Eleftheria-Kleio, University Hospital of Heraklion, Heraklion, Greece
  • Georgoulidou, Anastasia K, GENERAL HOSPITAL OF KOMOTINI, Komotini, Greece
  • Tsirpanlis, George I., "G.Gennimatas" General Hospital, Athens, Greece
  • Theodoridis, Marios, University Hospital of Alexandroupolis, Alexandroupolis, Greece
  • Mavromatidis, Konstantinos S, GENERAL HOSPITAL OF KOMOTINI, Komotini, Greece
  • Kyriazis, Periklis Panos, Beth israel Deaconess Medical Center, Brookline, Massachusetts, United States
  • Passadakis, Ploumis, University Hospital of Alexandroupolis, Alexandroupolis, Greece
  • Vlahakos, Dimitrios V., Attikon University Hospital, Athens, Greece
Background

To identify factors potentially capable of preventing the progression of abdominal aortic calcification (AAC), a surrogate of cardiovascular risk in PD patients

Methods

95 stable PD patients were studied (52 men), with a mean age of 62±15 years and a median dialysis vintage of 43 (IQR 28-71) months. The AAC was evaluated with Leena Kauppila (LK) score (range 0-24) on plain lateral abdominal radiographs. Patients were divided in a Low calcification score (CS) group: (LK score 0-4) and a High CS group: (LK score 5-24,), each comprising 38 (40%) and 57(60%) patients, respectively. Univariate and multivariate regression analysis were used to determine factors associated with a High CS.

Results

Mean CS in the whole group was 6.95±6.3. Patients with a High CS (10.8±5.1) were older, had a higher prevalence of diabetes (38.6 vs. 17.6%; p=0.04) and peripheral vascular disease (PVD) (29.8 vs. 10.5%; p=0.02), higher pulse pressure (PP) (57±14 vs. 51±15 mmHg; p=0.037) and malnutrition inflammation score (MIS) (5.12±3.1 vs. 3.8 ±2.7; p=0.039, lower serum magnesium (sMg) levels (2.12±0.36; vs. 2.37±0.54; p=0.008) and less use of cinacalcet (19.3 vs. 39.5%; p<0.03). In a multivariate analysis every 1mg/dl increase in sMg was associated with 74% lower odds of having a High CS (Table 1). MIS also emerged as a significant predictor of a high CS (Table 1). sMg was significantly (r=0.31; p=0.002) correlated with dialysate Mg concentration (0.50/0.25 mmol/L)

Conclusion

Our data indicate that sustaining higher sMg levels, as by using higher Mg dialysate concentration, and correcting the malnutrition and inflammation complex syndrome may potentially lower the AAC burden and, thus, improve cardiovascular risk in PD patients

Table 1
 UNIVARIATE MULTIVARIATE 
 OR (95%CI)POR (95%CI)P
Age (↑1 yr)1.08 (1.04–1.1)<0.0011.055 (1.009–1.1)0.018
Diabetes2.9 (1.007–8.5)0.048  
PVD3.6 (1.1–11.7)0.033  
PP (↑1 mmHg)1.03 (1001-1.06)0.04  
MIS (↑1 point)1.18 (1.004–1.37)0.041.25 (1.02–1.52)0.027
sMg (↑1mg/dl)0.28 (0.103–0.74)0.010.26 (0.07-0.94)0.04
Cinacalcet0.36 (0.14–0.92)0.04  

Funding

  • Clinical Revenue Support