Abstract: SA-PO766

Effect Modification by Age and Pulse Pressure (PP) on the Association Between Mediterranean Diet (MD) and Telomere Length (TL) in Hemodialysis (HD) Patients

Session Information

Category: Dialysis

  • 601 Standard Hemodialysis for ESRD

Authors

  • Markaki, Anastasia, Technological Educational Institute of Crete, Greece, Siteia, Greece
  • Bacharaki, Dimitra, ATTIKON UNIVERSITY HOSPITAL , Athens, Greece
  • Stylianou, Kostas, University Hospital of Heraklion, Heraklion, Greece
  • Vlahakos, Dimitrios V., None, Athens, Greece
  • Lygerou, Dimitra, University Hospital of Heraklion, Heraklion, Greece
  • Dermitzaki, Eleftheria-Kleio, University Hospital of Heraklion, Heraklion, Greece
  • Kyriazis, Periklis Panos, Beth israel Deaconess Medical Center, Brookline, Massachusetts, United States
  • Pilarinou, Andriana, Technological Educational Institute of Crete, Greece, Siteia, Greece
  • Gkouskou, Kalliopi K, Embiodiagnostics, Athens, Greece
  • Charonitaki, Aikaterini, Technological Educational Institute of Crete, Greece, Siteia, Greece
  • Kyriakidi, Konstantina, Technological Educational Institute of Crete, Greece, Siteia, Greece
  • Gioume, Argyro, Technological Educational Institute of Crete, Greece, Siteia, Greece
Background

TL is considered to be a biological marker for aging. Telomere shortening is associated with age-related health outcomes and risk of death. Here, we investigated whether the associations of greater adherence to a MD with longer TL depend on age and pulse pressure in HD patients

Methods

46 HD patients, (28 men) were studied. A MD adherence score (MDS range 0-55, 55 representing maximal adherence) was estimated using a previously reported method (Panagiotakos 2007).TL was measured from leukocyte DNA using a realtime PCR to measure T/S ratio, the ratio of telomere (T) to single copy gene (S) sequence. TL was analyzed as a dichotomous variable: above (High TL group) and below (Low TL group) the median value of T/S ratio (1.13)

Results

Patients in the high TL group were younger in age (56±14 vs. 70±9 years; p<0.001), had higher MDS (30±4 vs. 28±3; P=0.037) and lower PP (58±14 vs.68±14 mmHg; p=0.02), prevalence of diabetes mellitus (DM)(8.7 vs. 34.8 %; p=0.032) and peripheral vascular disease (PVD) (30.4 vs. 65.2%; p=0.018). Logistic regression analysis, after adjusting for age, PP, DM and PVD, showed that MDS was associated with longer TL (OR=1.6, 95%CI: 1.13-2.28; p=0.009).An interaction effect between MDS and age was significant (p=0.014), after controlling for the main effects, CVD, DM and PP. The same was true for the interaction between MDS and PP (p=0.006). Stratifying by age (above and below the median= 65 years), we found a significant association between MDS and TL in the younger age group (OR=2.269, 95%CI: 1.021-5.042; p=0.044), but not in the older patients. Also, stratifying by PP tertiles (first <56 mmHg vs. second and third), a significant association between MDS and TL was detected in the high PP group (OR=1.49, 95%CI: 1.051-2.13; p=0.025). Similar results were obtained when TL was examined as a continuous variable.

Conclusion

Our results show that adherence to a MD is associated with longer TL in patients under the age of 65 and in patients with increased arterial stiffness (PP>56 mmHg), indicating that adoption of a MD may have beneficial effects in these specific subgroups of HD patients.

Funding

  • Clinical Revenue Support