Abstract: TH-PO349

A Rare Case of Secondary Amyloidosis with Kidney and Colon Involvement in Chordoma

Session Information

Category: Acute Kidney Injury

  • 002 AKI: Repair and Regeneration

Authors

  • Ziaolhagh, Ali, University of Texas health Science Center at Houston, Housotn, Texas, United States
  • Selamet, Umut, MD Anderson Cancer Center, Houston, Texas, United States
  • Glass, William F., University of Texas – Houston Medical School, Houston, Texas, United States
  • Tchakarov, Amanda, University of Texas Medical School at Houston, Houston, Texas, United States
  • Abudayyeh, Ala, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Background

Amyloidosis is characterized by extracellular deposition of abnormal proteins. Secondary Amyloidosis (AA) is associated with infectious, inflammatory and malignant diseases. Among neoplastic diseases, AA is mostly associated with renal cell carcinoma, Gastrointestinal (GI) stromal tumors, and intestinal carcinomas

Methods

We present a case of AA with GI and kidney involvement due to sacral chordoma. Patient presented with diarrhea and proteinuria. Colonoscopy showed severe colitis. Pathology findings suggested amyloidosis. He had nephrotic range proteinuria, renal biopsy showed amyloidosis with no monoclonal deposition and confirmed to be secondary with mass spectrometry. He had extensive diarrhea and history of recurrent ileus. He presented with normal renal function, but due to ongoing diarrhea, he had hypotension and developed acute renal failure.

Conclusion

Secondary amyloidosis in association with cancers are reported as case-reports in the literature. However, to the best of authors’ knowledge, chordoma has never been reported as a cause of AA with severe systemic disease.