Abstract: FR-PO383

Uric Acid and Renal Pathological Features: A Cross-Sectional Study of 1070 Patients Receiving Renal Biopsy

Session Information

Category: Chronic Kidney Disease (Non-Dialysis)

  • 301 CKD: Risk Factors for Incidence and Progression

Authors

  • Wang, Li, Sichuan Provincial People's Hospital, Chengdu, China
  • Hong, Daqing, Sichuan Provincial People's Hospital, Chengdu, China
Background


Hyperuricemia(HUA) is very common in Chronic kidney disease. Hyperuricemia increases the risk of cardiovascular events and accelerates the progression of chronic kidney disease. Our study attempt to determine the relationship between baseline uric acid levels and renal pathological features.

Methods


1070 patients receiving renal biopsy in our center were involved in our study. The baseline characteristics at the time of kidney biopsy were collected from the medical records, including age, gender, serum uric acid(UA), glomerular filtration rate (eGFR), serum creatinine(Scr),Urea, 24 hours urine protein quantitation(24-u-pro),and serum albumin(Alb). Pathological morphological changes were evaluated with Oxford classification scoring system. Statistical analysis was done with SPSS 21.0.

Results

In the whole cohort,429 of 1070 were IgA nephropathy(IgAN),641 of 1070 were non-IgAN. The prevalence of HUA was 61.2%(n=655), 56.2%(n=241), and 64.6%(n=414) in all patients, IgAN and non-IgAN patients, respectively. Serum uric acid levels were correlated to eGFR (r=-0.418,P<0.001), Scr(r=0.391,,P<0.001), Urea(r=0.410 ,P<0.001), and 24-u-pro(r=0.077,P=0.022). Univariate logistic regression analysis showed that HUA was associated with higher risk factor for segmental glomerulosclerosis (OR=1.918, 95%CI: 1.444-2.546) and tubular atrophy or interstitial fibrosis(OR=3.279, 95%CI:2.037-5.276). Multivariate logistic regression analysis showed that after adjustment of Scr,HUA was still a risk factor for segmental glomerulosclerosis (OR=1.783, 95%CI:1.327-2.397) and tubular atrophy or interstitial fibrosis(OR=1.715, 95%CI:1.000-2.942).

Conclusion

Hyperuricemia is prevalent in CKD patients receiving renal biopsy. Uric acid correlates not only to clinical renal injury indexes including serum creatinine, eGFR, urine protein, but also to renal pathology. Hyperuricemia is independently associated with segmental glomerulosclerosis and tubular atrophy or interstitial fibrosis. Reduce uric acid levels may delay the progression of worsening renal function.