Abstract: FR-PO512

Renal Resistive Index and Systematic Arterial Stiffness in the General Population

Session Information

Category: Chronic Kidney Disease (Non-Dialysis)

  • 304 CKD: Epidemiology, Outcomes - Non-Cardiovascular

Authors

  • Fan, Xiaohong, Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences & Peking Union Medical College, Peiking, China
  • Li, Xuemei, Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences & Peking Union Medical College, Peiking, China
Background

Recent studies show that increased renal resistive index (RRI) is associated with kidney disease progression and cardiovascular disease (CVD). Greater arterial stiffness is also considered to be an independent predictor for CVD onset and associated with steeper decline in kidney function. RRI is presumed to be dependent on systematic vascular changes; however, the data about arterial stiffness and RRI is limited.

Methods

This study consisted of 3589 subjects ages between 35 and 85, recruited for a cross-sectional health survey in Pinggu, a suburb of Beijing, China in 2014. All subjects underwent assessment of ultrasonographic RRI and measurement of brachial-ankle pulse wave velocity (baPWV). Multiple linear regression modeling was performed to explore the RRI risk factors and the relationship between RRI and baPWV.

Results

The mean age of the study population was 53.7±9.1 years, 48.7% were males. RRI was positively associated with age (r=0.43; P<0.001). RRI in women was significantly higher than that in men (0.62±0.05 vs. 0.60±0.06; P<0.001) at all age groups, the sex difference existed even when adjusting for other factors. In all participants, baPWV was independently associated with increased RRI in multivariable analyses after adjustment for potential confounders. The other determinants of RRI in the general population were age, sex, systolic and diastolic blood pressure, body mass index, estimate glomerular filtration rate and hemoglobin A1c(Table 1).

Conclusion

There was significantly association between systematic arterial stiffness and interenal RRI. The sex difference affect needs to be investigated in the future.

Table 1: BaPWV was significantly associated with increased renal resistive index.
VariablesAll participants(n=3598)
beta95% CIP value
Gender,Female vs. Male0.0230.0200.026<0.0001
baPWV, per 1 m/s0.0010.00040.00180.001
age,per 1y0.0020.00170.0021<0.0001
BMI, per 1Kg/m20.00070.00020.00110.003
SBP, per 1mmHg0.0010.00090.0011<0.0001
DBP, per 1mmHg-0.001-0.0021-0.0018<0.0001
eGFR, per 1ml/min/1.73m20.00020.000080.00040.004
HbA1c, per 1%0.0040.0030.006<0.0001

Funding

  • Government Support - Non-U.S.