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Kidney Week

Abstract: SA-PO452

Prevalence and Associated Factors of Depressive Symptoms among Predialysis CKD Patients in China: Results from the Chinese Cohort Study of CKD (C-STRIDE)

Session Information

Category: Chronic Kidney Disease (Non-Dialysis)

  • 306 CKD: Cognitive Dysfunction, Depression, Quality of Life


  • Pu, Lei, Sichuan Provincial People''s Hospital, Chengdu, China
  • Wang, Li, Sichuan Provincial People''s Hospital, Chengdu, China
  • Li, Guisen, Renal Division and Institute of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People?s Hospital, Chengdu, China

Group or Team Name

  • C-STRIDE study group

Depression was reported to be the most common mental disorder in patients with chronic kidney disease (CKD). Previous studies found that depression could accelerate the progression of CKD disease, and was an independent risk factor of hospitalization and death among patients with CKD. The objective of this study is to investigate the prevalence of depression in Chinese patients with predialysis CKD, and to identify factors associated with depression.


Baseline data of a multicenter prospective cohort study, Chinese cohort study of chronic kidney disease(C-STRIDE)study were used. Altogether 2995 participants with CKD stage 1 to 4 who completed a survey of depressive symptoms were included. The depressive symptoms were assessed by Zung Self-Rating Depression Scale (ZSDS). ZSDS≥50 was used as thecutoff score of the presence of depressive symptoms. MultivariableLogistic regression models were used to identify factors associated with depression.


Mean eGFR level was 51.59±29.49ml/min/1.73m2. The prevalence of depressive symptoms was 37.8% and increased significantly with advanced CKD stages. Female, higher education level, low income, larger economic impact of disease cost, comorbid cardiovascular disease, anemia, lower physical activity ability were independently associated with depressive symptoms.


Our study revealed that depressive symptoms were common among Chinese predialysis CKD population. Socioeconomic factors andclinical characteristics of severity of disease were strongly associated with the depressive symptoms.