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Kidney Week

Abstract: FR-PO506

Association of Body Composition with Frailty Status among Patients with Moderate to Advanced CKD

Session Information

Category: Chronic Kidney Disease (Non-Dialysis)

  • 304 CKD: Epidemiology, Outcomes - Non-Cardiovascular


  • Delgado, Cynthia, San Francisco Department of Veterans Affairs, San Francisco, California, United States
  • Johansen, Kirsten L., University of California, San Franicsco, San Francisco, California, United States

Frailty disproportionately affects individuals with chronic kidney disease (CKD) and is associated with hospitalization and loss of independence. The Frailty In Chronic Kidney diSease Intervention pilot sTudy (FICKSIT) aimed to determine the feasibility of a multi-faceted intervention to address frailty. We compared body composition of frail and non-frail patients enrolled in FICKSIT.


We enrolled 68 patients with CKD stage III-IV over the age of 18 who were receiving nephrology care. Frailty was defined according to the Fried Frailty index, which includes 5 criteria (weak grip, exhaustion, weight loss, low physical activity, slow gait). Participants meeting three or more criteria were considered frail (F); those meeting 1-2 criteria were intermediate frail (IF); and those not meeting any frailty criteria were not frail (NF). We performed whole-body bioelectrical impedance spectroscopy (BIS) to estimate ICW/kg as a proxy for muscle mass (ICW)), fat mass (FM) and extracellular water (ECW) as a percentage of total body weight. We used ANOVA to compare frailty status (F, IF and NF) and logistic regression analysis with NF participants as the reference group to determine if body composition was associated with frailty status after adjusting for covariates.


Participants’ mean age was 67 ± 8, and 93% were male. The majority of participants met at least one frailty criterion; 49% were IF and 25% were F. ICW/kg was lower among IF (0.28 ± 0.3 L/kg) and F (0.26 ± 0.3 L/kg) than among NF participants (0.29 ± 0.03 L/kg, p=0.05). In regression analysis, higher percent muscle mass (ICW/kg) (OR 0.38 per 1%, 95%CI 0.17, 0.83) and percent FM (FM/kg) (OR 0.76 per 1%, 95%CI 0.58, 0.98) were associated with lower odds of frailty.


Among FICKSIT participants, higher muscle and fat mass were associated with lower odds of frailty


  • NIDDK Support