Abstract: SA-PO758
In-Vitro Dialysate Regeneration Using Dharma, the EasyDial Portable Hemodialysis Machine
Session Information
- Standard Hemodialysis for ESRD - I
November 04, 2017 | Location: Hall H, Morial Convention Center
Abstract Time: 10:00 AM - 10:00 AM
Category: Dialysis
- 601 Standard Hemodialysis for ESRD
Authors
- Khawar, Osman S., Balboa Nephrology Medical Group, Escondido, California, United States
- Mcnamara, Timothy R., EasyDial, Irvine, California, United States
- Foster, Sarah L, EasyDial, Irvine, California, United States
Background
Dharme is a unique, fully portable dialysis machine, which uses only 5 Liters of dialysate per treatment. In order to achieve this limited dialysate volume, dialysate is regenerated using a chemical filter through which dialysate in recirculated continuously during dialysis, while electrolyes are supplied via an infusion into the dialysate reservior.
Methods
Bovine blood was tested during a 2 hour dialysis, using a 70 mL concentrated mixture of calcium, potassium, and magnesium administered continuously during into 5 Liters of dialysate using an ambIT peristalitc pump. Samples of dialysate were collected every 15 minutes and analyzed for electrolyte concentrations.
Results
The electrolytes were continuously present at acceptable concentations, indicating that dialyate was regenerated during the dialysis.
Concentrations are provided in table 1. Baseline and 2 hour concentrations for each ion were: Calcium 37.06 ppm 36.67ppm, Magnesium 10.63ppm and 13.58ppm, potassium 71.03ppm and 5.15ppm.
Conclusion
These results verify that continuous infusion of key electrolytes into the dialysate during dialysis with Dharma maintains electrolyte concentrations in regenerated dialysate. Dharma offers the unique features of portability (18 lbs), no fixed water connection (5L dialysate) and the possilbiity for significantly reducing dialysis treatment times.
Electrolyte Concentrations in Dialysate
| Calcium | Magnesium | Potassium | |
| Time | ppm | ppm | ppm |
| 0 | 37.96 | 10.63 | 71.03 |
| 15 | 31.65 | 9.29 | 53.2 |
| 30 | 47.07 | 15.42 | 42.02 |
| 60 | 60.44 | 17.82 | 9.49 |
| 75 | 41.15 | 14.38 | 5.26 |
| 90 | 35.47 | 13.21 | 3.13 |
| 105 | 36.03 | 13.45 | 3.1 |
| 120 | 36.67 | 13.58 | 5.15 |
Funding
- Commercial Support – EasyDial Inc