Abstract: FR-PO1077

Twelve Weeks of Home-Based Exercise Training Improves Strength, Function and Quality-of-Life Measures in Elderly Hemodialysis Patients

Session Information

Category: Dialysis

  • 601 Standard Hemodialysis for ESRD

Authors

  • Chan, Khin N., VA Palo Alto Health Care System, Stanford, California, United States
  • Massaband, Payam, VA Palo Alto Health Care System, Stanford, California, United States
  • Lit, Yiming, VA Palo Alto Health Care System, Stanford, California, United States
  • Chen, Yu, VA Palo Alto Health Care System, Stanford, California, United States
  • Niu, Tieming, VA Palo Alto Health Care System, Stanford, California, United States
  • Myers, Jonathan N., VA Palo Alto Health Care System, Stanford, California, United States
Background


Maintenance hemodialysis (MHD) patients exhibit significantly impaired physical function and skeletal muscle wasting. We examined whether 12 weeks of home-based exercise training improves cardiopulmonary function, muscle mass, strength, QOL, and cognitive function in elderly MHD patients.

Methods

Twenty-three elderly MHD patients (66 ± 7.7 yrs) were randomized to either a 12-week home-based exercise program (n=9) or usual care (n=14). Measures of peak VO2, thigh muscle quality (percentage intramuscular fat [IMF]) evaluated by magnetic resonance imaging (MRI), body composition by DXA scan, upper and lower body strength, six-minute walk test (6MWT), and QoL were determined.

Results

Peak VO2 (ml/kg/min) increased 13% in the exercise group while no significant changes occurred among controls. Exercise time improved 44% in the exercise group while there was 14% reduction among controls (p=0.06). There were no significant changes in thigh muscle IMF % by MRI or leg fat % by DXA in either group. Distance covered during the 6MWT was marginally improved in both groups. Number of sit-to-stand repetitions in 1 minute was improved by 10% in the exercise group and was unchanged in usual care. Exercised patients improved 12 % in lower body strength. Both physical and mental component scores were improved by approximately 12% in the exercise group.

Conclusion

In this interim analysis, we observed that 12 weeks of exercise training is potentially effective in improving cardiopulmonary function, strength and quality of life in elderly MHD patients.

Table 1. Exercise capacity, strength, and quality of life measures in the exercise and control groups before and after the 12-week period.

Funding

  • Veterans Affairs Support