ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Autosomal Dominant Tubulointerstitial Kidney Disease: New Diagnostics and Therapies

November 03, 2022 | 04:30 PM - 06:00 PM

Location: WF1 Tangerine, Orange County Convention Center‚ West Building

Session Description

Autosomal dominant tubulointerstitial kidney disease (ADTKD) has heterogeneous genetic causes and collectively accounts for a significant proportion of CKD. This session provides an overview of basic science, animal models, and human studies in some of the genetic causes, including REN, UMOD, MUC1, and PKD1/2.

Learning Objective(s)

  • Describe the diagnosis and genetic causes of ADTKD
  • Outline the different models of ADTKD
  • Interpret the translation of research findings to potential future therapies

Learning Pathway(s)

  • Genetic Diseases and Development
  • CKD Non-Dialysis


  • Anthony J. Bleyer, MD, MS, FASN
  • Ronak Lakhia, MD


  • Landscape of REN Mutations
    04:30 PM - 04:50 PM
    Martina Zivna, MSc, PhD
  • UMOD Disease Genetics and Models
    04:50 PM - 05:10 PM
    Luca Rampoldi, PhD
  • MUC1 Biology and Models
    05:10 PM - 05:30 PM
    Anna Greka, MD, PhD
  • Kidney Plasticity Revealed Through Reversal of PKD in Mice
    05:30 PM - 05:50 PM
    Stefan Somlo, MD
  • Q&A
    05:50 PM - 06:00 PM