Kidney Week

Basic/Clinical Science Session

Navigating Human Leukocyte Antigens

November 06, 2025 | 04:30 PM - 06:00 PM

Location: Room 332A, Convention Center

Session Description

Human leukocyte antigen (HLA) crossmatch is a crucial component of pretransplant donor-recipient compatibility assessment. Traditional cell-based crossmatch has played a pivotal role in eliminating the risks of hyperacute antibody-mediated rejection, but there are drawbacks, including false-positive rates, impact on cold ischemia time, and logistical challenges. Virtual crossmatch has been increasingly used in lieu of cell-based crossmatch to address such challenges.

Learning Objective(s)

• Define the role of virtual crossmatch in deceased donor kidney transplantation
• Discuss the current state of desensitization for highly sensitized kidney transplant recipients
• Describe machine-learning approaches to HLA risk stratification

Learning Pathway(s)

• Kidney Transplantation

Moderators

• Enver Akalin, MD, FASN
• Elaine F. Reed, PhD

Presentations

• Virtual Crossmatch in Kidney Transplantation: When and How?
  04:30 PM - 04:50 PM
  
  • Anat R. Tambur, PhD

Virtual Crossmatch in Kidney Transplantation: When and How?

November 06, 2025 | 04:30 PM - 04:50 PM

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• Desensitization in Kidney Transplantation: What's New?
  04:50 PM - 05:10 PM
  
  • Carmen Lefaucheur, MD, PhD

Desensitization in Kidney Transplantation: What's New?

November 06, 2025 | 04:50 PM - 05:10 PM

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• Use of Advanced HLA Epitope and Eplet Matching to Stratify Immunologic Risk
  05:10 PM - 05:30 PM
  
  • Chris J. Wiebe, MD

Use of Advanced HLA Epitope and Eplet Matching to Stratify Immunologic Risk

November 06, 2025 | 05:10 PM - 05:30 PM

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• Machine-Learning Approaches to HLA-Based Risk Stratification in Kidney Transplantation
  05:30 PM - 05:50 PM
  
  • Jenny N. Tran, PhD

Machine-Learning Approaches to HLA-Based Risk Stratification in Kidney Transplantation

November 06, 2025 | 05:30 PM - 05:50 PM

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• Q&A
  05:50 PM - 06:00 PM
  

Q&A

November 06, 2025 | 05:50 PM - 06:00 PM

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