Abstract: SA-PO284

Distribution of Glomerular Diseases in Taiwan: Preliminary Report of National Renal Biopsy Registry – Report on Behalf of Taiwan Society of Nephrology

Session Information

Category: Glomerular

  • 1005 Clinical Glomerular Disorders

Authors

  • Chiu, Hsien-Fu, Taichung Veteran General Hospital, Taichung, Taiwan
  • Lu, Kuo-cheng, Division of Nephrology, Department of Medicine, Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
  • Chen, Hung-Chun, Kaohsiung Medical Univ, Taiwan, Taiwan
  • Shu, Kuo-hsiung, Lin Shin Hospital, Taichung, Taiwan
Background

Despite the development of biomarkers and noninvasive imaging tools, biopsy remains the only method for correctly diagnosing patients with unexplained hematuria, proteinuria and renal failure. Renal biopsy has been performed for several decades in Taiwan; however, a national data registry is still lacking until 2013.

Methods

The Renal Biopsy Registry Committee was established within the Taiwan Society of Nephrology in January 2013. A biopsy registry format, including basic demographic data, baseline clinical features, laboratory data, and clinical and pathological diagnosis was developed. Approval from the local institutional review board was obtained in each participating medical center.

Results

From January 2014 to September 2016, 1445 renal biopsies were identified from 17 medical centers. 53.8% cases were reported in men. The mean age at biopsy was 48.4±16.6 years. The median serum creatinine was 1.6 (IQR 0.9-3.3) mg/dL. The median daily urine protein was 2.7 (IQR 0.7-6.8) g/day, whereas 57.3% patients had hematuria.Primary glomerulonephritis (GN), secondary GN, tubulointerstitial diseases, and post-renal transplantation accounted for 40.7%, 33.6%, 10.3%, and 15.3%, respectively. Among primary GN, IgA nephropathy (26.0%), focal segmental glomerulosclerosis (FSGS) (21.6%), and membranous nephropathy (MGN) (20.6%) were most frequently diagnosed. Diabetic nephropathy (22.4%) and lupus nephritis (21.8%) were the most common among secondary GN. Patients with minimal change disease (MCD) and MGN had heavier proteinuria than those with FSGS and IgA nephropathy. The most common cause of nephrotic syndrome in primary glomerular disease was MGN (28.8%), followed by MCD (28.2%). IgA nephropathy was the leading cause of chronic nephritic syndrome,acute nephritic syndrome,and persistent hematuria. The incidence was 0.55, 0.47, 0.45, and 0.41 in 100,000/year for IgA nephropathy, FSGS, MGN, and MCD,respectively. The incidence of primary GN was 2.19 in 100,000/year.

Conclusion

This is the first report of the National Renal Biopsy Registry in Taiwan. IgA nephropathy is the most common primary GN, while MGN is the most common cause of nephrotic syndrome. Primary GN distribution in Taiwan is slightly different from that in other Asian countries.