Kidney Week

Abstract: TH-PO441

Beverage Consumption and Kidney Disease Risk

Session Information

• Nutrition, Inflammation, Metabolism: Basic Mechanisms
  November 02, 2017 | Location: Hall H, Morial Convention Center
  Abstract Time: 10:00 AM - 10:00 AM

Category: Nutrition, Inflammation, and Metabolism

• 1401 Nutrition, Inflammation, Metabolism

Authors

• Rebholz, Casey, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States

Casey Rebholz,

• Young, Bessie A., Uniiversity of Washington, Seattle, Washington, United States

Bessie A. Young,

• Katz, Ronit, University of Washington, Seattle, Washington, United States

Ronit Katz,

• Auerbach, Brandon J., University of Washington, Seattle, Washington, United States

Brandon J. Auerbach,

• Tucker, Katherine L, University of Massachusetts Lowell, Lowell, Massachusetts, United States

Katherine L Tucker,

• Carithers, Teresa Carr, University of Mississippi, Oxford, Mississippi, United States

Teresa Carr Carithers,

• Norwood, Arnita Ford, University of Mississippi Medical Center, Jackson, Mississippi, United States

Arnita Ford Norwood,

• Okhomina, Victoria I, University of Mississippi Medical Center, Jackson, Mississippi, United States

Victoria I Okhomina,

• Correa, Adolfo, University of Mississippi Medical Center, Jackson, Mississippi, United States

Adolfo Correa,

Background

Sugar-sweetened beverages have been the target of health policies to reduce obesity and related cardiometabolic diseases. Identifying beverages that are associated with chronic kidney disease (CKD) risk could inform dietary guidelines.

Methods

We conducted a prospective analysis of participants in the Jackson Heart Study, a cohort of African-American men and women in Jackson, Mississippi. Beverage intake was assessed using a food frequency questionnaire administered at baseline (2000-04). Incident CKD was defined as eGFR <60 mL/min/1.73 m² and ≥30% eGFR decline at follow-up (2009-13) relative to baseline among those with baseline eGFR ≥60 mL/min/1.73 m². Logistic regression was used to estimate the association between the consumption of each individual beverage (energy-adjusted using the residual method), beverage patterns, and incident CKD. Beverage patterns were empirically-derived using principal components analysis (PCA) in which components were created based on the linear combinations of beverages consumed.

Results

Among 3,402 participants, 220 (6.5%) developed incident CKD over a median follow-up of 8 years. At baseline, median age was 54 years, 63% were female, and median eGFR was 98 mL/min/1.73 m². After adjusting for total energy intake, age, sex, income, body mass index, smoking, physical activity, hypertension, diabetes, high density lipoprotein cholesterol, history of cardiovascular disease, and baseline eGFR, higher intake of sweetened fruit drinks was significantly associated with increased risk of CKD (OR=1.12, 95% CI: 1.00, 1.27, p=0.05). A PCA-derived beverage pattern consisting of higher consumption of soda, sweetened fruit drinks, and water was more strongly associated with incident CKD (OR=1.23, 95% CI: 1.08, 1.41, p=0.002) than any beverage alone. No other individual types of beverages or beverage patterns were associated with CKD.

Conclusion

Higher consumption of sweetened fruit drinks was associated with elevated risk of subsequently developing CKD in this community-based population of African-Americans.

Funding

• NIDDK Support