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Abstract: TH-PO441

Beverage Consumption and Kidney Disease Risk

Session Information

Category: Nutrition, Inflammation, and Metabolism

  • 1401 Nutrition, Inflammation, Metabolism


  • Rebholz, Casey, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States
  • Young, Bessie A., Uniiversity of Washington, Seattle, Washington, United States
  • Katz, Ronit, University of Washington, Seattle, Washington, United States
  • Auerbach, Brandon J., University of Washington, Seattle, Washington, United States
  • Tucker, Katherine L, University of Massachusetts Lowell, Lowell, Massachusetts, United States
  • Carithers, Teresa Carr, University of Mississippi, Oxford, Mississippi, United States
  • Norwood, Arnita Ford, University of Mississippi Medical Center, Jackson, Mississippi, United States
  • Okhomina, Victoria I, University of Mississippi Medical Center, Jackson, Mississippi, United States
  • Correa, Adolfo, University of Mississippi Medical Center, Jackson, Mississippi, United States

Sugar-sweetened beverages have been the target of health policies to reduce obesity and related cardiometabolic diseases. Identifying beverages that are associated with chronic kidney disease (CKD) risk could inform dietary guidelines.


We conducted a prospective analysis of participants in the Jackson Heart Study, a cohort of African-American men and women in Jackson, Mississippi. Beverage intake was assessed using a food frequency questionnaire administered at baseline (2000-04). Incident CKD was defined as eGFR <60 mL/min/1.73 m2 and ≥30% eGFR decline at follow-up (2009-13) relative to baseline among those with baseline eGFR ≥60 mL/min/1.73 m2. Logistic regression was used to estimate the association between the consumption of each individual beverage (energy-adjusted using the residual method), beverage patterns, and incident CKD. Beverage patterns were empirically-derived using principal components analysis (PCA) in which components were created based on the linear combinations of beverages consumed.


Among 3,402 participants, 220 (6.5%) developed incident CKD over a median follow-up of 8 years. At baseline, median age was 54 years, 63% were female, and median eGFR was 98 mL/min/1.73 m2. After adjusting for total energy intake, age, sex, income, body mass index, smoking, physical activity, hypertension, diabetes, high density lipoprotein cholesterol, history of cardiovascular disease, and baseline eGFR, higher intake of sweetened fruit drinks was significantly associated with increased risk of CKD (OR=1.12, 95% CI: 1.00, 1.27, p=0.05). A PCA-derived beverage pattern consisting of higher consumption of soda, sweetened fruit drinks, and water was more strongly associated with incident CKD (OR=1.23, 95% CI: 1.08, 1.41, p=0.002) than any beverage alone. No other individual types of beverages or beverage patterns were associated with CKD.


Higher consumption of sweetened fruit drinks was associated with elevated risk of subsequently developing CKD in this community-based population of African-Americans.


  • NIDDK Support