Abstract: TH-PO162

Cross Sectional Study on the Clinical Manifestations of Focal Segmental Glomerular Sclerosis (FSGS) in Japan from the Data of the Japan-Renal Biopsy Registry (J-RBR)

Session Information

Category: Glomerular

  • 1005 Clinical Glomerular Disorders

Authors

  • Ozeki, Takaya, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Maruyama, Shoichi, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Kawaguchi, Takehiko, National Hospital Organization Chiba-East Hospital, Chiba, Japan
  • Imasawa, Toshiyuki, National Hospital Organization Chiba-East Hospital, Chiba, Japan
  • Katafuchi, Ritsuko, National Fukuoka-Higashi Medical Center, Koga, Fukuoka, Japan
  • Sato, Hiroshi, Clinical Pharamacology and Therapeutics, Graduate School of pharmaceutical Sciences, Tohoku University, Sendai, Japan
Background

Even though the clinical manifestations of FSGS varies amomg the underlying etiology, few reports had described the detail of its features comparing with MCD.
J-RBR: Japanese nationwide registry started in 2007 and it has 32870 biopsy cases until December 2016. The aim of this study was to clarify the clinical characteristics of FSGS through analyzing the data of J-RBR.

Methods

A cross sectional study; patients were diagnosed with FSGS or MCD and were registered in J-RBR during 2007-2016.
<Analysis 1> 1409 cases who were registered with histopathological diagnosis of FSGS were divided to 3 subgroups by age; Children (<18)/ Adult (18-64)/ Elderly (65≤), and clinical parameters were compared between subgroups.
<Analysis 2>To compare the clincal features between nephrotic FSGS and MCD, patients who filfilled the criteria below were selected from the database. Criteria; histopathological diagnosis as FSGS or MCD, clinical diagnosis of nephrotic syndrome and over 18 years old.

Results

<Analysis 1>Among the 3 groups; Children (n=166), Adult (n=904), Elderly (n=339), the percentages of clinical diagnosis of nephrotic syndrome was 62.1, 32.9, 56.1 respectively. Adult group showed the lowest incidence of nephrotic syndrome.
<Analysis 2>As compared with MCD (n=1522), FSGS (n=419) patients had higher age (FSGS: 59 vs MCD: 47.5) and higher rate of hypertension. And FSGS patients showed lower kidney finction (creatinine: 1.03 vs 0.83 mg/dL), higher serum albumin (2.2 vs 1.8 g/dL) and lower unine protein level (5.40 vs 6.28 g/day) at biopsy.

Conclusion

The incidence of nephrotic syndrome in FSGS patients was different among the age groups. Although FSGS patients showed lower kidney function and relatively milder proteinuria compared with MCD, it seemed to be difficult to distinguish these diseases only by initial clinical informations.