Abstract: FR-PO380

Relation of Uric Acid with Rapid Kidney Function Decline and Development of Kidney Disease: The Jackson Heart Study

Session Information

Category: Chronic Kidney Disease (Non-Dialysis)

  • 301 CKD: Risk Factors for Incidence and Progression

Authors

  • Mwasongwe, Stanford, Jackson State University, Jackson, Mississippi, United States
  • Fulop, Tibor, FMC Organ Replacement Center, University of Debrecen, Debrecen, Hungary
  • Musani, Solomon K, University of Mississippi Medical Center , JACKSON, Mississippi, United States
  • Sims, Mario, University of Mississippi Medical Center , JACKSON, Mississippi, United States
  • Correa, Adolfo, University of Mississippi Medical Center, Jackson, Mississippi, United States
  • Young, Bessie A., Uniiversity of Washington, Seattle, Washington, United States
  • Flessner, Michael F., NIDDK, NIH, Bethesda, Maryland, United States
Background

Reports on whether elevated uric acid represents an independent risk factor for development and progression of chronic kidney disease (CKD) have been mixed. We evaluated the relationship of uric acid level with rapid kidney function decline (RKFD) and incident CKD among 3,702 Jackson Heart Study participants who had complete measures of uric acid at baseline (2000-2004) and estimated glomerular filtration rate (eGFR) available at both baseline and Exam 3 (2009-2013).

Methods

RKFD was defined as a decline in eGFR of ≥30% between Exams while incident CKD was defined as having eGFR < 60 mL/minute/1.73 m2 at Exam 3 with ≥ 25% eGFR decline. Associations were evaluated using multiple logistic regression models. Odds ratios (OR, 95% confidence [CI]) were reported per 1 standard deviation (SD) increment.

Results

Mean baseline uric acid and eGFR were 5.4 ±1.6 mg/dL and 95.9 ±19.9 mL/min/1.73 m2, respectively. During a median follow-up of 8.1 years, 422 (11.4%) and 268 (7.5%) participants experienced RKFD and developed incident CKD, respectively. In multivariable logistic regression, 1 SD increase in baseline uric acid concentration was associated with increased odds for RKFD (OR 1.8; 95% CI 1.25-2.49; p = 0.0013) and suggested a potential risk for incident CKD (OR, 1.39; 95% CI 0.89-2.16; p = 0.14). There was no interaction between sex and uric acid on both RKFD (p = 0.12) and incident CKD (p = 0.70).

Conclusion

In the community-based cohort of African Americans, elevated serum uric acid was significantly associated with RKFD and may represent a risk factor for development of CKD.

Funding

  • Other NIH Support