Kidney Week

Abstract: FR-PO450

Augmented Effect of Blood Pressure on Renal Arteriolosclerosis via Increased Arterial Stiffness in CKD

Session Information

• CKD: Risk Factors for Incidence and Progression - II
  November 03, 2017 | Location: Hall H, Morial Convention Center
  Abstract Time: 10:00 AM - 10:00 AM

Category: Chronic Kidney Disease (Non-Dialysis)

• 301 CKD: Risk Factors for Incidence and Progression

Authors

• Zamami, Ryo, University of the Ryukyus, Nishihara-cho, Japan

Ryo Zamami,

• Miyagi, Tsuyoshi, University of the Ryukyus, Nishihara-cho, Japan

Tsuyoshi Miyagi,

• Kohagura, Kentaro, University of the Ryukyus, Nishihara-cho, Japan

Kentaro Kohagura,

• Yamazato, Masanobu, University of the Ryukyus, Nishihara-cho, Japan

Masanobu Yamazato,

• Ishida, Akio, University of the Ryukyus, Nishihara-cho, Japan

Akio Ishida,

• Ohya, Yusuke, University of the Ryukyus, Nishihara-cho, Japan

Yusuke Ohya,

Background

We reported arteriolar hyalinosis, a potential marker for disrupted autoregulation system may potentiate hypertensive glomerular damage. Arterial stiffness is suggested to relate hypertensive organ damage by interaction with arteriolar sclerosis. Therefore, we conducted a cross-sectional study to determine the effect of arterial stiffness on the relationship between blood pressure and renal arteriolar hyalinosis.

Methods

A total of 102 consecutive patients with chronic kidney disease (CKD) who underwent renal biopsy and had data of branchial-ankle pulse wave velocity (baPWV) were recruited. Arteriolar hyalinosis was semiquantitatively assessed via grading system (grade 0 –3).

Results

The mean value for age, blood pressure and estimated glomerular filtration rate (eGFR) were as follows: 46 years, 123/74 mmHg, and 72ml/min/1.73m². Patients were divided into four subgroup according to the median value of baPWV and systolic BP (SBP). Max hyalinosis grade was the highest in high baPWV / high SBP group. In multivariate logistic regression analysis, revealed that high baPWV / high SBP were significantly associated with the presence of highest max hyalinosis grade 3 (Odds ratio, 8.22; 95% confidence interval 1.79-37.7, P<0.01). Moreover, this group had the highest urine protein among four groups. Even in normal SBP, patients with high baPWV had higher max hyalinosis grade compared with low baPWV.

Conclusion

In CKD patients, arterial remodeling may cause progression of CKD via augmented effect of blood pressure on renal arteriolosclerosis.