Abstract: TH-PO1053

Association between Mineral Metabolism Parameters and Carotid Intima Media Thickness in a Cardiovascular Risk Population (CORDIOPREV Study)

Session Information

Category: Mineral Disease

  • 1201 Mineral Disease: Ca/Mg/PO4

Authors

  • Rodriguez Ortiz, Maria Encarnacion, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC). Reina Sofia University Hospital/University of Córdoba, Córdoba, Spain
  • Almaden peña, Yolanda, Lipid and Atherosclerosis Unit. IMIBIC/Reina Sofia University Hospital/University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
  • Gómez-Delgado, Francisco, Lipid and Atherosclerosis Unit. IMIBIC/Reina Sofia University Hospital/University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
  • Arenas-Larriva, Antonio, Lipid and Atherosclerosis Unit. IMIBIC/Reina Sofia University Hospital/University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
  • Canalejo, Antonio, Department of Integrated Sciences, University of Huelva, Huelva, Spain
  • Gómez-Luna, Purificación, Lipid and Atherosclerosis Unit. IMIBIC/Reina Sofia University Hospital/University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
  • Herencia, Carmen maria, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC). Reina Sofia University Hospital/University of Córdoba, Córdoba, Spain
  • López-Moreno, Javier, Lipid and Atherosclerosis Unit. IMIBIC/Reina Sofia University Hospital/University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
  • Rodriguez, Mariano, Nephrology Service. Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC). Reina Sofía University Hospital/University of Córdoba, Córdoba, Spain
  • López-Miranda, José, Lipid and Atherosclerosis Unit. IMIBIC/Reina Sofia University Hospital/University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
Background

Cardiovascular diseases (CVD) are the main cause of mortality in patients with Mineral Metabolism (MM) alterations, as those with CKD. Thus, factors related to MM may play a key role in the onset and development of CVD. Carotid intima media thickness (IMT-CC) has shown strong associations with well-recognized risk factors of CVD and it is a predictor of coronary artery disease. The aim of this study was to assess whether there is an association between some key parameters of MM and the IMT-CC in a cardiovascular risk population.

Methods

This work was carried out in the setting of the CORDIOPREV study (Clinical Trials 128 Registry NCT0092493741), a prospective, randomized, controlled trial including 1,002 patients aged 20-75 years with coronary heart disease. Carotid arteries were examined bilaterally using a Doppler ultrasound high-resolution B-mode. IMT-CC was calculated as the mean of three measurements. Basal plasma levels of FGF23, Ca, P, creatinine (Cr), Mg, 25-OH and calcitriol (CTR) were measured.

Results

As shown in the table (mean±SE), a significant inverse relationship was observed between IMT-CC and eGFR and Mg, while Cr and FGF23 were directly associated with IMT-CC.

Conclusion

Even within the normal range, there was an association between some MM parameters and the IMT-CC in a cardiovascular risk population. Thus, these factors might be useful for the monitoring of CVD.

Grant ISCIII (PI14/00872)

Table
 IMT-CC (mm) 
 Q1 (0.43-0.61)Q2 (0.62-0.70)Q3 (0.71-0.80)Q4 (0.81-1.27)P-value
eGFR (ml/min)95.4±1.395.9±1.490.9±1.489.5±1.40.001
Cr (mg/dl)0.87±0.010.85±0.010.91±0.010.93±0.010.001
P (mg/dl)3.57±0.053.58±0.053.62±0.053.60±0.050.883
Mg (mg/dl)1.89±0.031.90±0.031.76±0.031.62±0.03<0.001
Ca (mg/dl)9.56±0.039.51±0.039.59±0.039.59±0.030.195
FGF23 (pg/ml)40.3±1.439.9±1.545.3±1.550.4±1.5<0.001
25OH (ng/ml)16.0±2.716.6±0.516.4±0.516.7±0.50.814
CTR (pg/ml)64.4±2.762.6±2.861.4±2.760.7±2.80.791