Abstract: TH-PO106

Clinical and Pathological Differences in Patients with IgA Nephropathy with IgG Deposit and Position in Glomeruli

Session Information

Category: Glomerular

  • 1004 Clinical/Diagnostic Renal Pathology and Lab Medicine

Authors

  • Xing, Chang Ying, First Affiliated Hospital of Nanjing Medical University, Nanjing, JIANGSU , China
  • Zheng, Yanfang, First Affiliated Hospital of Nanjing Medical University, Nanjing, JIANGSU , China
Background

It is not clear the clinical data, pathological changes in patients with IgA Nephropathy with or without IgG deposition in glomeruli. This paper is to explore the significance of IgG deposit in glomeruli in patients with IgA Nephropathy.

Methods

There were 327 patients with IgA nephropathy diagnosed by renal biopsy in our hospital in the past 2 years. All renal biopsy samples were examined by light microscopy and immunofluorescence. IgA nephropathy patients were divided into two groups: IgA+IgG group (n=82) with IgG deposit in glomerli, and IgA group (n=245) without IgG deposit. Patients in IgA+IgG group were divided 2 subgroups according to the position of IgG deposit,deposit in mesangial area(10) and along glomerular basement membrane(72).

Results

Patients with IgA Nephropathy in IgA+IgG group had more 24 hours urine protein, higher serum creatinine, uric acid, hypertension and lower complement C4,eGFR than those in IgA group(P<0.05). The score of renal tubular atrophy/interstitial fibrosis (T) was higher IgA+IgG group than that in IgA group (P<0.05). There was no significant difference in proliferation of mesangial cells, mesangial hypercellularity, segmental glomerulosclerosis or adhesion, hyperplasia of endocapillary cell (P>0.05). Patients with IgG deposits along glomerular basement membrane(GBM) subgroup had more numbers, younger age, higher blood pressure than those in patients with IgG deposit in mesangial area subgroup(P<0.05). The eGFR, urea nitrogen and uric acid in IgG along GBM deposit subgroup were lower than those in the IgG deposit in mesangial area subgroup (P<0.05).There was no significant difference in the pathological changes between the two subgroups (P>0.05).

Conclusion

The patients with IgA nephropathy with IgG deposition are younger, more 24 hours urine protein, higher serum creatinine, and hypertension. Even the different position of IgG deposit in glomeruli may also have different clinical significance. We should strengthen the understanding of IgA nephropathy with IgG deposition and delay the progress of IgA nephropathy.