Kidney Week

Abstract: SA-PO184

Association between Decrease in Skeletal Muscle Mass Index and Renal Atrophy in Patients with Non-Dialysis CKD

Session Information

• Nutrition, Inflammation, Metabolism: Clinical Trials, Biomarkers, Epidemiology
  November 04, 2017 | Location: Hall H, Morial Convention Center
  Abstract Time: 10:00 AM - 10:00 AM

Category: Nutrition, Inflammation, and Metabolism

• 1401 Nutrition, Inflammation, Metabolism

Authors

• Iio, Rei, Osaka General Medical Center, Osaka, Japan

Rei Iio,

• Kumamoto, Rika, Osaka General Medical Center, Osaka, Japan

Rika Kumamoto,

• Takatsuka, Taisuke, Osaka General Medical Center, Osaka, Japan

Taisuke Takatsuka,

• Yoshimura, Daisuke, Osaka General Medical Center, Osaka, Japan

Daisuke Yoshimura,

• Okushima, Hiroki, Osaka General Medical Center, Osaka, Japan

Hiroki Okushima,

• Iwata, Yukimasa, Osaka General Medical Center, Osaka, Japan

Yukimasa Iwata,

• Kensuke, Mitsumoto, Osaka General Medical Center, Osaka, Japan

Mitsumoto Kensuke,

• Shoji, Tatsuya, Osaka General Medical Center, Osaka, Japan

Tatsuya Shoji,

• Hayashi, Terumasa, Osaka General Medical Center, Osaka, Japan

Terumasa Hayashi,

Background

The frequency of sarcopenia increases as chronic kidney disease (CKD) progresses. CKD patients should be screened for sarcopenia and presarcopenia in order to detect them during an earlier stage of CKD and improve prognosis. Kidney size is associated with aging, inflammation, and decreased renal function, as seen with sarcopenia. We investigated the association of kidney size with muscle mass and muscle mass change in CKD patients.

Methods

We performed a single-center retrospective cohort study of 180 non-dialysis dependent CKD patients (age 66.4±12.5 years; male 66.1%; eGFR 31.4±17.5 mL/min/1.73m²; etiology glomerulonephritis 22.2%, diabetic nephropathy 23.9%). We measured kidney size by ultrasonography and calculated total kidney volume (TKV) using an ellipsoid equation. Skeletal muscle mass index (SMI) were estimated using bioelectrical impedance analysis, and presarcopenia was defined as SMI ≤7.0 kg/m² for men and ≤5.7 kg/m² for women. The rate of change in SMI over a 6-month period was evaluated.

Results

The mean rate of change in SMI in six months was -1.5±7.1%. Multivariate logistic regression analysis showed that TKV was associated with presarcopenia (OR: 0.98, 95% confidential interval: 0.97-1.00, p=0.041). Multivariate regression analysis showed that SMI (β: -3.95, SE: 0.92, p<0.001) and TKV (β: 0.037, SE: 0.015, p=0.016) were associated with the rate of change of SMI in six months adjusted for age, sex, BMI, diabetes mellitus, history of cardiovascular disease, serum albumin, and proteinuria.

Conclusion

Among patients with CKD, presarcopenia is significantly associated with TKV, and patients with a small TKV are more prone to developing a decrease in skeletal muscle mass.