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Abstract: SA-PO1089

Previous Aerobic Exercise Increases Vo2 Peak in Rats with Kidney Chronic Disease

Session Information

Category: Hypertension

  • 1102 Hypertension: Basic and Experimental - Renal Causes and Consequences

Authors

  • Silva, Wesley, Universidade Federal de São Paulo, Sao Paulo [SP], Brazil
  • Luiz, Rafael, Universidade Federal de São Paulo , São Paulo, Brazil
  • Saud, Alexandre, Universidade Federal de São Paulo , São Paulo, Brazil
  • Reinecke, Natalia, Universidade Federal de São Paulo , São Paulo, Brazil
  • Filho, Samuel Trindade, Universidade Federal de São Paulo , São Paulo, Brazil
  • Silva, Kleiton Augusto Santos, University of Missouri, Columbia, Alabama, United States
  • Rampaso, Rodolfo Rosseto, Universidade Federal de São Paulo , São Paulo, Brazil
  • Jorge, Luciana, Universidade Federal de São Paulo , São Paulo, Brazil
  • Schor, Nestor, Universidade Federal de São Paulo , São Paulo, Brazil
Background

Chronic Kidney Disease (CKD) contributes to harm the renal and cardiovascular function. The Aerobic exercise training have been used widely to modulation of renal and cardiovascular environment, reducing cardiovascular risk-associated diseases. Aim: To evaluate the effects of the previous exercise training (PET) on oxygen consumption peak (VO2 peak) and renal function of rats submitted to nephrectomy 5/6

Methods

Wistar rats (n=5), were randomically divided in four groups: Exercise + NX + exercise (ENXE), exercise + NX + sedentary (ENXS), sedentary + NX + sedentary (SNXS). Treadmill exercise was performed at 40 to 60% of VO2 peak for 8 weeks. NX surgery was perfomed on 4th week of exercise training protocol

Results

The VO2 peak and exercise capacity were improved in NXES and NXEE groups compared to NXSS. Exercise training decreased proteinuria, although, it was not observed changes in creatinine clearance, serum creatinine and urinary volume. Systolic arterial pressure decreased in NXEE when compared to NXSS and NXES

Conclusion

The data suggest that exercise training may be applied to patients with CKD, especially when performed previous onset of the disease. Thus it demonstrated that exercise were effective to prevent death in NXES and NXEE and could be an addition strategy to treatment of CKD patients

 NXSSNXESNXEE
Proteinuria (mg/24)
196.4 ± 16.4

193.6 ± 12.6

132.2 ± 14.9 *#

Creatinine serum (mg/dL)


1.2 ± 0.1

1.4 ± 0.1


1.4 ± 0.1


Creatinine Clearance (ml/min)

0.4 ± 0.1

0.8 ± 0.2

0.6 ± 0.1

Blood pressure (mm/Hg)

250 ± 5

249 ± 2

225 ± 1 *#

Urinary volume (ml/24h)

46.2 ± 4

32 ± 9

37 ± 1


VO2 peak (ml/kg/min)

20.6 ± 0.4

27.5 ± 2.1 *

37.8 ± 1.4 *#

Maximum load test (m/min)

28 ± 230 ± 1 40 ± 1 *#

* vs NXSS; # vs NXES; p<0,05