Abstract: TH-PO125

Prevalence of Occult Hepatitis C Infection in Patients with Glomerulopathies and Chronic Renal Disease: A Pilot Study

Session Information

Category: Glomerular

  • 1004 Clinical/Diagnostic Renal Pathology and Lab Medicine

Authors

  • Sette, Luis H.B.C., UNIVERSIDADE FEDERAL DE PERNAMBUCO, Recife, Pernambuco, Brazil
  • Augusto vieira de oliveira, Savio, Laboratório de Imunogenética, RECIFE, PERNAMBUCO, Brazil
  • dos Anjos, Nathalia Campello Guedes, University Federal of Pernambuco, RECIFE, PERNAMBUCO, Brazil
  • Lucena-Silva, Norma, Laboratório de Imunogenética, RECIFE, PERNAMBUCO, Brazil
  • Lopes, Edmundo Pessoa, UNIVERSIDADE FEDERAL DE PERNAMBUCO, Recife, Pernambuco, Brazil
Background

The Occult Hepatitis C Infection (OHCI) is characterized by the presence of the genetic viral material on polymorphonuclear cells (PMNC), plasma ultracentrifugation or hepatic tissue in the absence of antibodies in the serum. It has been demonstrated a high prevalence of OHCI in patients with glomerulopathies (GP), suggesting a pathophysiological association between the virus and GP. It is also known that there is a higher prevalence of chronic HCV infection in patients with dialytic chronic kidney disease (CKD) and that IOHC can be acquired before renal replacement therapy initiation. Therefore, this study aimed to evaluate the prevalence of OHCI in patients with GP and with CKD.

Methods

Patients were evaluated from April to August 2016. Patients younger than 18 years of age, pregnant, infected with HBV, HCV and HIV and less than 3 months of follow-up were excluded. PCR for hepatits C RNA were investigated in serum, plasma ultracentrifuged and PMNC.

Results

We evaluated 126 of which 56 were excluded. Of the 64 remaining patients, 32 were GP patients. Demographic and clinical data are shown in Table 1. When analyzing patients for OHCI, a prevalence of 18.2% was observed in patients with GP. Among the patients with CKD, the prevalence was 6.25%. Although there is almost 3-fold prevalence among cases of OHCI in patients with GP it was not statistically significant (p=0.35), probably due to the small number of patients enroled.

Conclusion

The existence of OHCI was observed in patients with GP and in pre-dialytic CKD. The prevalence in patients with GP was about three times higher than that observed in patients with CKD.

Baseline characteristics
 GP
(n=32)
CKD
(n=32)
p
Gender, female (%)62.543.7 
AGE (SD)38.7 ± 13.660.9 ± 15.2 
BMI (Kg/m2), ± SD25.5 ± 5.827.2 ± 4.4p<0.001
Acumputure (n,%)2 (6.2)0 
Tatoo (n,%)5 (15.6)1 (3.1)p=0.19
Hemotransfusion, n (%)12 (37.5)9 (28.2)p=0.18
Sexual transmited disease(n,%)6 (18.7)11 (34.4)p=0.004
Piercing n,%6 (18.7)0 
Previous Dialysis (n, %)3 (9.3)2 (6.2)p=0.28
eGFR (mL/min/1.73m2) ± SD
(CKD-EPI)
78.1 ± 33.523.5 ± 11.8p<0.001
OHCI n (%)6 (18.2)2 (6.2)p=0.34

OHCI: occult HCV infection;